Schizophrenia, psychotropic medication, and cataract

McCarty, Cathy A., Wood, Carolyn A., Fu, Cara L., Livingston, Patricia M., Mackersey, Sue, Stanislavsky, Yury and Taylor, Hugh R. 1999, Schizophrenia, psychotropic medication, and cataract, Ophthalmology, vol. 106, no. 4, pp. 683-687, doi: 10.1016/S0161-6420(99)90151-3.

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Title Schizophrenia, psychotropic medication, and cataract
Author(s) McCarty, Cathy A.
Wood, Carolyn A.
Fu, Cara L.
Livingston, Patricia M.ORCID iD for Livingston, Patricia M.
Mackersey, Sue
Stanislavsky, Yury
Taylor, Hugh R.
Journal name Ophthalmology
Volume number 106
Issue number 4
Start page 683
End page 687
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 1999-04-01
ISSN 0161-6420
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Summary OBJECTIVE: To compare the distribution of cataract types between psychiatric patients diagnosed with schizophrenia and the general population not exposed to psychotropic medication, and to compare cataract prevalence between users and nonusers of various psychotropic medications in the general community. DESIGN: Case-control. PARTICIPANTS: A total of 151 (93%) eligible patients from a community mental health service and 3271 (83%) eligible residents from the Melbourne Visual Impairment Project (VIP) were examined. MAIN OUTCOME MEASURES: All patients 40 years of age and older from a community mental health service and residents of nine randomly selected areas of Melbourne were eligible. Best-corrected distance visual acuity was determined using a 4-m logarithm of the minimum angle of resolution (LogMAR) chart. The presence of cataract was determined by photographs or slit-lamp examination using direct and indirect retroillumination. Anterior, cortical, nuclear, and posterior subcapsular cataracts were measured. Participants from the Melbourne VIP were classified as to whether they had taken benzodiazepams, phenothiazines, thioxanthenes, butyrophenols, tricyclic antidepressants, or monoamine oxidase inhibitors for at least 12 months during their lifetime. RESULTS: The distribution of cataract type varied between persons with and without schizophrenia. Anterior subcapsular (ASC) cataract was significantly more prevalent (26%) in participants with schizophrenia from the community mental health service than Melbourne VIP participants (0.2%) not exposed to psychotropic medication (chi-square, 1 degree of freedom = 605.5, P = 0.001). This remained significant after controlling for age (odds ratios = 250, 95% confidence interval = 83.3, 1000). The distribution of the age-related cataract was similar across all groups of psychotropic medication users with the exception of the phenothiazine users. They had less of all types of the age-related cataracts, despite being slightly older than the control group (mean age, 60.0 vs. 58.4, t test = 0.85, P = 0.40). However, only cortical cataract in the phenothiazine group was statistically lower (chi-square, 1 degree of freedom = 3.96, P = 0.047). CONCLUSION: This study has identified the need to investigate whether other newer agents, especially high-potency medications, cause ASC opacities if a certain threshold of exposure to psychotropic medications must be attained to develop cataract, or if schizophrenia itself is associated with cataract formation.
Language eng
DOI 10.1016/S0161-6420(99)90151-3
Field of Research 1103 Clinical Sciences
1113 Ophthalmology And Optometry
1117 Public Health And Health Services
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, Elsevier
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