Prognostic value of fat mass and skeletal muscle mass determined by computed tomography in patients who underwent transcatheter aortic valve implantation

Mok, Michael, Allende, Ricardo, Leipsic, Jonathon, Altisent, Omar Abdul-Jawad, del Trigo, Maria, Campelo-Parada, Francisco, DeLarochellière, Robert, Dumont, Eric, Doyle, Daniel, Côté, Mélanie, Freeman, Melanie, Webb, John and Rodés-Cabau, Josep 2016, Prognostic value of fat mass and skeletal muscle mass determined by computed tomography in patients who underwent transcatheter aortic valve implantation, American journal of cardiology, vol. 117, no. 5, pp. 828-833, doi: 10.1016/j.amjcard.2015.12.015.

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Title Prognostic value of fat mass and skeletal muscle mass determined by computed tomography in patients who underwent transcatheter aortic valve implantation
Author(s) Mok, MichaelORCID iD for Mok, Michael orcid.org/0000-0003-1839-2316
Allende, Ricardo
Leipsic, Jonathon
Altisent, Omar Abdul-Jawad
del Trigo, Maria
Campelo-Parada, Francisco
DeLarochellière, Robert
Dumont, Eric
Doyle, Daniel
Côté, Mélanie
Freeman, Melanie
Webb, John
Rodés-Cabau, Josep
Journal name American journal of cardiology
Volume number 117
Issue number 5
Start page 828
End page 833
Total pages 6
Publisher Elsevier
Place of publication Atlanta, Ga.
Publication date 2016-03-01
ISSN 0002-9149
1879-1913
Summary Body composition (fat mass [FM] and skeletal muscle mass [SMM]) predicts clinical outcomes. In particular, loss of SMM (sarcopenia) is associated with frailty and mortality. There are no data on the prevalence and impact of FM and SMM in patients undergoing transcatheter aortic valve implantation (TAVI). The objective of this study is to determine body composition from pre-TAVI computed tomography (CT) and evaluate its association with clinical outcomes in patients who underwent TAVI. A total of 460 patients (mean age 81 ± 8 years, men: 51%) were included. Pre-TAVI CTs of the aorto-ilio-femoral axis were analyzed for FM and SMM cross-sectional area at the level of the third lumbar vertebrae (L3). Regression equations correlating cross-sectional area at L3 to total body FM and SMM were used to determine prevalence of sarcopenia, obesity, and sarcopenic obesity in patients (64%, 65%, and 46%, respectively). Most TAVI procedures were performed through a transfemoral approach (59%) using a balloon-expandable valve (94%). The 30-day and mid-term (median 12 months [interquartile range 6 to 27]) mortality rates were 6.1% and 29.6%, respectively. FM had no association with clinical outcomes, but sarcopenia predicted cumulative mortality (hazard ratio 1.55, 95% confidence interval 1.02 to 2.36, p = 0.04). In conclusion, body composition analysis from pre-TAVI CT is feasible. Sarcopenia, obesity, and sarcopenic obesity are prevalent in the TAVI population, with sarcopenia predictive of cumulative mortality.
Language eng
DOI 10.1016/j.amjcard.2015.12.015
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
1102 Cardiovascular Medicine And Haematology
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081888

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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