Design and conduct of a pragmatic randomized controlled trial to enhance smoking-cessation outcomes with exercise: The Fit2Quit study

Maddison, Ralph, Roberts, Vaughan, Bullen, Chris, McRobbie, Hayden, Jiang, Yannan, Prapavessis, Harry, Glover, Marewa, Taylor, Sue and Brown, Paul 2010, Design and conduct of a pragmatic randomized controlled trial to enhance smoking-cessation outcomes with exercise: The Fit2Quit study, Mental health and physical activity, vol. 3, no. 2, pp. 92-101, doi: 10.1016/j.mhpa.2010.09.003.

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Title Design and conduct of a pragmatic randomized controlled trial to enhance smoking-cessation outcomes with exercise: The Fit2Quit study
Author(s) Maddison, RalphORCID iD for Maddison, Ralph
Roberts, Vaughan
Bullen, Chris
McRobbie, Hayden
Jiang, Yannan
Prapavessis, Harry
Glover, Marewa
Taylor, Sue
Brown, Paul
Journal name Mental health and physical activity
Volume number 3
Issue number 2
Start page 92
End page 101
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2010-12-01
ISSN 1755-2966
Keyword(s) Physical activity
Nicotine replacement therapy
Self-efficacy theory
Summary Background: Most smokers want to stop smoking and many try to quit. However abstinence rates are low and most smokers do not manage to abstain for even a week. Relapse to smoking can be related to the occurrence of tobacco withdrawal symptoms (e.g., sleep disturbance, irritability, and craving) and weight gain. If regular exercise mitigates these effects it could have potential as an aid to smoking cessation. The aim of the Fit2Quit study is to determine the effects of a home and community-based exercise intervention on smoking abstinence at six months when used as an adjunct to usual care (telephone smoking-cessation counseling and nicotine replacement therapy; NRT). Methods/design: A prospective parallel two-arm randomized controlled trial. Participants (n = 1400, 700 per arm) will be randomized to a structured home and community-based exercise program plus usual care (behavioral counseling and NRT) or to usual-care alone. It is targeted that at least 25% of the sample will be of Mori ethnicity (New Zealand indigenous). Outcomes to be measured using intention-to-treat analysis include: seven-day point prevalence of smoking abstinence verified by salivary cotinine (primary outcome); 6 months continuous abstinence; body mass index (BMI); cardio-respiratory fitness; physical activity levels; and cost effectiveness. Discussion: The Fit2Quit study is an example of a large, pragmatic randomized controlled trial in a community setting. Specific components of the exercise intervention are outlined in detail. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12609000637246.
Language eng
DOI 10.1016/j.mhpa.2010.09.003
Field of Research 111799 Public Health and Health Services not elsewhere classified
1103 Clinical Sciences
1106 Human Movement And Sports Science
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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