The PREPARE pilot RCT of home-based progressive resistance exercises for venous leg ulcers

Jull, A., Parag, V., Walker, N., Maddison, R., Kerse, N. and Johns, T. 2009, The PREPARE pilot RCT of home-based progressive resistance exercises for venous leg ulcers, Journal of wound care, vol. 18, no. 12, pp. 497-503, doi: 10.12968/jowc.2009.18.12.45606.

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Title The PREPARE pilot RCT of home-based progressive resistance exercises for venous leg ulcers
Author(s) Jull, A.
Parag, V.
Walker, N.
Maddison, R.ORCID iD for Maddison, R.
Kerse, N.
Johns, T.
Journal name Journal of wound care
Volume number 18
Issue number 12
Start page 497
End page 503
Total pages 7
Publisher Mark Allen Group
Place of publication London, Eng
Publication date 2009-12
ISSN 0969-0700
Keyword(s) venous ulcer
progressive resistant exercise
wound healing
randomised controlled trial
Summary OBJECTIVE: To establish the feasibility of conducting a home-based progressive resistance exercise programme to improve calf muscle pump function in community-based patients with venous leg ulcers. METHOD: Participants were randomised to receive a 12-week progressive resistance exercise programme using heel raises in addition to compression. The control was usual care in addition to compression. Randomisation was stratified by ulcer duration and ulcer size. Air plethysmography was used to determine changes in calf muscle pump function from baseline. Changes in ulcer parameters were measured using the SilhouetteMobile device. RESULTS: Forty participants were randomised. There were significantly greater improvements in ejection fraction of the calf muscle in the exercise group compared with the control (usual care) group (mean difference 18.5%, 95% CI 0.03 to 36.6%, p<0.05). Other parameters improved in the exercise group but the mean differences were not significant. Adherence with prescribed exercises was 81% and there was no significant difference in the numbers reporting adverse events. There were also no significant differences in ulcer healing parameters (change in area, percentage change in area, number healed at 12 weeks, time to healing). CONCLUSION: A community-based randomised trial of progressive resistance exercise is feasible. The prescribed exercises appeared to increase ejection fraction, but the effect of exercise on ulcer healing requires further investigation.
Language eng
DOI 10.12968/jowc.2009.18.12.45606
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
1110 Nursing
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2009, Mark Allen Group
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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