Openly accessible

Statin and aspirin use and the risk of mood disorders among men

Williams, Lana J., Pasco, Julie A., Mohebbi, Mohammadreza, Jacka, Felice N., Stuart, Amanda L., Venugopal, Kamalesh, O'Neil, Adrienne and Berk, Michael 2016, Statin and aspirin use and the risk of mood disorders among men, The international journal of neuropsychopharmacology, vol. 19, no. 6, pp. 1-4, doi: 10.1093/ijnp/pyw008.

Attached Files
Name Description MIMEType Size Downloads
williams-statinandaspirin-2016.pdf Published version application/pdf 711.30KB 44

Title Statin and aspirin use and the risk of mood disorders among men
Author(s) Williams, Lana J.ORCID iD for Williams, Lana J. orcid.org/0000-0002-1377-1272
Pasco, Julie A.ORCID iD for Pasco, Julie A. orcid.org/0000-0002-8968-4714
Mohebbi, MohammadrezaORCID iD for Mohebbi, Mohammadreza orcid.org/0000-0001-9713-7211
Jacka, Felice N.ORCID iD for Jacka, Felice N. orcid.org/0000-0002-9825-0328
Stuart, Amanda L.ORCID iD for Stuart, Amanda L. orcid.org/0000-0001-8770-9511
Venugopal, Kamalesh
O'Neil, Adrienne
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name The international journal of neuropsychopharmacology
Volume number 19
Issue number 6
Start page 1
End page 4
Total pages 4
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2016
ISSN 1469-5111
Keyword(s) aspirin
cytokines
depression
epidemiology
immune system
inflammation
mood disorder
prevention
statins
Summary Background: There is a growing understanding that depression is associated with systemic inflammation. Statins and aspirin have anti-inflammatory properties. Given these agents have been shown to reduce the risk of a number of diseases characterized by inflammation, we aimed to determine whether a similar relationship exists for mood disorders (MD).

Methods: This study examined data collected from 961 men (24–98 years) participating in the Geelong Osteoporosis Study. MD were identified using a semistructured clinical interview (SCID-I/NP). Anthropometry was measured and information on medication use and lifestyle factors was obtained via questionnaire. Two study designs were utilized: a nested case-control and a retrospective cohort study.

Results: In the nested case-control study, exposure to statin and aspirin was documented for 9 of 142 (6.3%) cases and 234 of 795 (29.4%) controls (P < .001); after adjustment for age, exposure to these anti-inflammatory agents was associated with reduced likelihood of MD (OR 0.2, 95%CI 0.1–0.5). No effect modifiers or other confounders were identified. In the retrospective cohort study of 836 men, among the 210 exposed to statins or aspirin, 6 (2.9%) developed de novo MD during 1000 person-years of observation, whereas among 626 nonexposed, 34 (5.4%) developed de novo MD during 3071 person-years of observation. The hazard ratio for de novo MD associated with exposure to anti-inflammatory agents was 0.55 (95%CI 0.23–1.32).

Conclusions: This study provides both cross-sectional and longitudinal evidence consistent with the hypothesis that statin and aspirin use is associated with a reduced risk of MD.
Language eng
DOI 10.1093/ijnp/pyw008
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082041

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in TR Web of Science
Scopus Citation Count Cited 11 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 444 Abstract Views, 46 File Downloads  -  Detailed Statistics
Created: Wed, 09 Mar 2016, 12:26:11 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.