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Niacin skin sensitivity is increased in adolescents at ultra-high risk for psychosis

Berger, Gregor E., Smesny, Stefan, Schäfer, Miriam R., Milleit, Berko, Langbein, Kerstin, Hipler, Uta-Christina, Milleit, Christine, Klier, Claudia M., Schlögelhofer, Monika, Holub, Magdalena, Holzer, Ingrid, Berk, Michael, McGorry, Patrick D., Sauer, Heinrich and Amminger, G. Paul 2016, Niacin skin sensitivity is increased in adolescents at ultra-high risk for psychosis, PLoS one, vol. 11, no. 2, Article number: e0148429, pp. 1-17, doi: 10.1371/journal.pone.0148429.

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Title Niacin skin sensitivity is increased in adolescents at ultra-high risk for psychosis
Author(s) Berger, Gregor E.
Smesny, Stefan
Schäfer, Miriam R.
Milleit, Berko
Langbein, Kerstin
Hipler, Uta-Christina
Milleit, Christine
Klier, Claudia M.
Schlögelhofer, Monika
Holub, Magdalena
Holzer, Ingrid
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
McGorry, Patrick D.
Sauer, Heinrich
Amminger, G. Paul
Journal name PLoS one
Volume number 11
Issue number 2
Season Article number: e0148429
Start page 1
End page 17
Total pages 17
Publisher PLoS
Place of publication San Francisco, Calif.
Publication date 2016
ISSN 1932-6203
Keyword(s) adolescent
adult
enzyme activation
fatty acids
female
flushing
humans
Intracellular Space
male
niacin
phospholipases a2
psychotic disorders
risk
skin
young adult
Summary BACKGROUND: Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders.

METHODS: We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics.

RESULTS: Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (inPLA2) activity, a marker of membrane lipid repair/remodelling.

CONCLUSIONS: Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a "pro-inflammatory state", whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated.
Language eng
DOI 10.1371/journal.pone.0148429
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082050

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Created: Wed, 09 Mar 2016, 13:21:38 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.