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Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder

Scarr, E., Gray, L., Keriakous, D., Robinson, P. J. and Dean, B. 2006, Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder, Bipolar disorders, vol. 8, no. 2, pp. 133-143, doi: 10.1111/j.1399-5618.2006.00300.x.

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Title Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder
Author(s) Scarr, E.
Gray, L.
Keriakous, D.
Robinson, P. J.
Dean, B.
Journal name Bipolar disorders
Volume number 8
Issue number 2
Start page 133
End page 143
Total pages 11
Publisher Wiley
Place of publication London, Eng.
Publication date 2006-04
ISSN 1398-5647
1399-5618
Summary Objective:  In order to identify whether the mechanisms associated with neurotransmitter release are involved in the pathologies of bipolar disorder and schizophrenia, levels of presynaptic [synaptosomal-associated protein-25 (SNAP-25), syntaxin, synaptophysin, vesicle-associated membrane protein, dynamin I] and structural (neuronal cell adhesion molecule and alpha-synuclein) neuronal markers were measured in Brodmann's area 9 obtained postmortem from eight subjects with bipolar I disorder (BPDI), 20 with schizophrenia and 20 controls.
Methods:  Determinations of protein levels were carried out using Western blot techniques with specific antibodies. Levels of mRNA were measured using real-time polymerase chain reaction.
Results:  In BPDI, levels of SNAP-25 (p < 0.01) and synaptophysin (p < 0.05) increased. There were no changes in schizophrenia or any other changes in BPDI. Levels of mRNA for SNAP-25 were decreased in BPDI (p < 0.05).
Conclusion:  Changes in SNAP-25 and synaptophysin in BPDI suggest that changes in specific neuronal functions could be linked to the pathology of the disorder.
Language eng
DOI 10.1111/j.1399-5618.2006.00300.x
Field of Research 1103 Clinical Sciences
1109 Neurosciences
110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2006, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082057

Document type: Journal Article
Collection: School of Medicine
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