Retinal tissue thickness is reduced in diabetic peripheral neuropathy

Srinivasan, Sangeetha, Pritchard, Nicola, Vagenas, Dimitrios, Edwards, Katie, Sampson, Geoff P., Russell, Anthony W., Malik, Rayaz A. and Efron, Nathan 2016, Retinal tissue thickness is reduced in diabetic peripheral neuropathy, Current eye research, vol. 41, no. 10, pp. 1359-1366, doi: 10.3109/02713683.2015.1119855.

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Title Retinal tissue thickness is reduced in diabetic peripheral neuropathy
Author(s) Srinivasan, Sangeetha
Pritchard, Nicola
Vagenas, Dimitrios
Edwards, Katie
Sampson, Geoff P.ORCID iD for Sampson, Geoff P. orcid.org/0000-0003-0145-5691
Russell, Anthony W.
Malik, Rayaz A.
Efron, Nathan
Journal name Current eye research
Volume number 41
Issue number 10
Start page 1359
End page 1366
Total pages 8
Publisher Taylor & Francis
Place of publication London, Eng.
Publication date 2016
ISSN 1460-2202
Keyword(s) Diabetic peripheral neuropathy
ganglion cell complex
neuropathy disability score
retinal nerve fiber layer
retinal thickness
Summary AIM: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness.

METHODS: Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0-10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1c levels.

RESULTS: In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1c levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04).

CONCLUSIONS: DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.
Language eng
DOI 10.3109/02713683.2015.1119855
Field of Research 111399 Ophthalmology and Optometry not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Taylor & Francis
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082077

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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