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Retinal tissue thickness in type 1 and type 2 diabetes

Srinivasan, Sangeetha, Pritchard, Nicola, Sampson, Geoff P., Edwards, Katie, Vagenas, Dimitrios, Russell, Anthony W., Malik, Rayaz A. and Efron, Nathan 2016, Retinal tissue thickness in type 1 and type 2 diabetes, Clinical and experimental optometry, vol. 99, no. 1, pp. 78-83, doi: 10.1111/cxo.12318.

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Title Retinal tissue thickness in type 1 and type 2 diabetes
Author(s) Srinivasan, Sangeetha
Pritchard, Nicola
Sampson, Geoff P.
Edwards, Katie
Vagenas, Dimitrios
Russell, Anthony W.
Malik, Rayaz A.
Efron, Nathan
Journal name Clinical and experimental optometry
Volume number 99
Issue number 1
Start page 78
End page 83
Total pages 6
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 2016-01
ISSN 1444-0938
Keyword(s) diabetic retinopathy
ganglion cell complex
retinal nerve fibre layer
retinal thickness
type 1 diabetes
type 2 diabetes
Science & Technology
Life Sciences & Biomedicine
Ophthalmology
Summary BACKGROUND: The objective was to investigate full retinal and inner retinal thickness in individuals with type 1 and type 2 diabetes. METHODS: Eighty-four individuals with type 1 diabetes (T1DM), 67 individuals with type 2 diabetes (T2DM) and 42 non-diabetic individuals (control group) were enrolled. Participants underwent full retinal thickness evaluation in the central retinal, parafoveal and perifoveal zones and in the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC), using spectral domain optical coherence tomography. As a preliminary step, the key variables of interest - age, sex, diabetic retinopathy (DR), duration of diabetes and HbA1c levels - were analysed and compared between the three groups. Full retinal thickness, RNFL and GCC thicknesses were also compared between the groups. The relationship between the type of diabetes and retinal tissue thickness was explored, adjusting for the five potential confounders. RESULTS: Compared to individuals with T1DM, individuals with T2DM had significantly reduced full retinal thickness in the parafovea and perifovea and reduced RNFL and GCC thickness. The mean differences were six (p = 0.020), seven (p = 0.008), six (p = 0.021) and four micrometres (p = 0.013) for the parafovea, perifovea, RNFL and GCC thicknesses, respectively. Thicknesses within the central zone (p = 0.018) and at the parafovea (p = 0.007) were significantly reduced in T2DM when compared to the control group. After adjusting for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels, the relationship between type of diabetes and retinal tissue thickness was not statistically significant (p > 0.056). CONCLUSION: Retinal tissue thickness is not significantly different between type 1 and type 2 diabetes, when adjusted for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels.
Language eng
DOI 10.1111/cxo.12318
Field of Research 111399 Ophthalmology and Optometry not elsewhere classified
Socio Economic Objective 920104 Diabetes
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Optometry Australia
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082200

Document type: Journal Article
Collection: School of Medicine
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Created: Tue, 15 Mar 2016, 10:18:44 EST

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