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Endurance training in early life results in long-term programming of heart mass in rats

Wadley, Glenn D., Laker, Rhianna C., McConell, Glenn K. and Wlodek, Mary E. 2016, Endurance training in early life results in long-term programming of heart mass in rats, Physiological reports, vol. 4, Article Number : e12720, pp. 1-14, doi: 10.14814/phy2.12720.

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Title Endurance training in early life results in long-term programming of heart mass in rats
Author(s) Wadley, Glenn D.ORCID iD for Wadley, Glenn D. orcid.org/0000-0002-6617-4359
Laker, Rhianna C.
McConell, Glenn K.
Wlodek, Mary E.
Journal name Physiological reports
Volume number 4
Season Article Number : e12720
Start page 1
End page 14
Total pages 14
Publisher Wiley
Place of publication London, Eng.
Publication date 2016
ISSN 2051-817X
Keyword(s) Endurance training
fetal programming
heart hypertrophy
Summary Being born small for gestational age increases the risk of developing adult cardiovascular and metabolic diseases. This study aimed to examine if early-life exercise could increase heart mass in the adult hearts from growth restricted rats. Bilateral uterine vessel ligation to induce uteroplacental insufficiency and fetal growth restriction in the offspring (Restricted) or sham surgery (Control) was performed on day 18 of gestation in WKY rats. A separate group of sham litters had litter size reduced to five pups at birth (Reduced litter), which restricted postnatal growth. Male offspring remained sedentary or underwent treadmill running from 5 to 9 weeks (early exercise) or 20 to 24 weeks of age (later exercise). Remarkably, in Control, Restricted, and Reduced litter groups, early exercise increased (P < 0.05) absolute and relative (to body mass) heart mass in adulthood. This was despite the animals being sedentary for ~4 months after exercise. Later exercise also increased adult absolute and relative heart mass (P < 0.05). Blood pressure was not significantly altered between groups or by early or later exercise. Phosphorylation of Akt Ser(473) in adulthood was increased in the early exercise groups but not the later exercise groups. Microarray gene analysis and validation by real-time PCR did not reveal any long-term effects of early exercise on the expression of any individual genes. In summary, early exercise programs the heart for increased mass into adulthood, perhaps by an upregulation of protein synthesis based on greater phosphorylation of Akt Ser(473).
Language eng
DOI 10.14814/phy2.12720
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082262

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