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Progressive computed tomography (CT) appearances preceding malignant spinal cord compression (MSCC) in men with castration-resistant prostate cancer

Pezaro, C., Omlin, A., Perez-Lopez, R., Mukherji, D., Attard, G., Bianchini, D., Lorente, D., Parker, C., Dearnaley, D., de Bono, J. S., Sohaib, A. and Tunariu, N. 2015, Progressive computed tomography (CT) appearances preceding malignant spinal cord compression (MSCC) in men with castration-resistant prostate cancer, Clinical radiology, vol. 70, no. 4, pp. 359-365, doi: 10.1016/j.crad.2014.05.104.

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Title Progressive computed tomography (CT) appearances preceding malignant spinal cord compression (MSCC) in men with castration-resistant prostate cancer
Author(s) Pezaro, C.
Omlin, A.
Perez-Lopez, R.
Mukherji, D.
Attard, G.
Bianchini, D.
Lorente, D.
Parker, C.
Dearnaley, D.
de Bono, J. S.
Sohaib, A.
Tunariu, N.
Journal name Clinical radiology
Volume number 70
Issue number 4
Start page 359
End page 365
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-04
ISSN 1365-229X
Keyword(s) Aged
Case-Control Studies
Humans
Male
Middle Aged
Prostatic Neoplasms, Castration-Resistant
Retrospective Studies
Spinal Cord Compression
Spinal Cord Neoplasms
Tomography, X-Ray Computed
Summary AIM: To test the hypothesis that computed tomography (CT)-based signs might precede symptomatic malignant spinal cord compression (MSCC) in men with metastatic castration-resistant prostate cancer (mCRPC). MATERIALS AND METHODS: A database was used to identify suitable mCRPC patients. Staging CT images were retrospectively reviewed for signs preceding MSCC. Signs of malignant paravertebral fat infiltration and epidural soft-tissue disease were defined and assessed on serial CT in 34 patients with MSCC and 58 control patients. The presence and evolution of the features were summarized using descriptive statistics. RESULTS: In MSCC patients, CT performed a median of 28 days prior to the diagnostic magnetic resonance imaging (MRI) demonstrated significant epidural soft tissue in 28 (80%) patients. The median time to MSCC from a combination of overt malignant paravertebral and epidural disease was 2.7 (0-14.6) months. Conversely, these signs were uncommon in the control cohort. CONCLUSIONS: Significant malignant paravertebral and/or epidural disease at CT precede MSCC in up to 80% of mCRPC patients and should prompt closer patient follow-up and consideration of early MRI evaluation. These CT-based features require further prospective validation.
Language eng
DOI 10.1016/j.crad.2014.05.104
Field of Research 1103 Clinical Sciences
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082276

Document type: Journal Article
Collection: School of Medicine
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