You are not logged in.

Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells

Li, Rui, Pavuluri, Sivapriya, Bruggeman, Kiara, Long, Benjamin M., Parnell, Andrew J., Martel, Anne, Parnell, Steven R., Pfeffer, Frederick M., Dennison, Andrew J. C., Nicholas, Kevin R., Barrow, Colin J., Nisbet, David R. and Williams, Richard J. 2016, Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells, Nanomedicine: nanotechnology, biology and medicine, vol. 12, no. 5, pp. 1397-1407, doi: 10.1016/j.nano.2016.01.009.

Attached Files
Name Description MIMEType Size Downloads

Title Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells
Author(s) Li, Rui
Pavuluri, Sivapriya
Bruggeman, Kiara
Long, Benjamin M.ORCID iD for Long, Benjamin M. orcid.org/0000-0002-3248-8851
Parnell, Andrew J.
Martel, Anne
Parnell, Steven R.
Pfeffer, Frederick M.ORCID iD for Pfeffer, Frederick M. orcid.org/0000-0002-5441-6437
Dennison, Andrew J. C.
Nicholas, Kevin R.
Barrow, Colin J.ORCID iD for Barrow, Colin J. orcid.org/0000-0002-2153-7267
Nisbet, David R.
Williams, Richard J.
Journal name Nanomedicine: nanotechnology, biology and medicine
Volume number 12
Issue number 5
Start page 1397
End page 1407
Total pages 12
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-07
ISSN 1549-9642
Keyword(s) bionanotechnology
cancer
hydrogels
self-assembly
supramolecular materials
tissue engineering
Summary The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications are the nanostructured scaffolds formed by epitope containing minimalist self-assembled peptides (SAPs), as they are bioactive on a cellular length scale, whilst presenting as an easily handled hydrogel. Here, we show that the assembly process distributes an anti-inflammatory polysaccharide, fuccoidan, localised to the nanofibers to function as an anti-inflammatory biomaterial for cancer therapy. We show that it supports healthy cells, whilst inducing apoptosis in cancerous endothelial cells, as demonstrated by the downregulation of the proinflammatory gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications as local epithelial cancer immunotherapy and drug delivery vehicles.
Language eng
DOI 10.1016/j.nano.2016.01.009
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
030401 Biologically Active Molecules
060103 Cell Development, Proliferation and Death
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082384

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in TR Web of Science
Scopus Citation Count Cited 7 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 185 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Mon, 21 Mar 2016, 13:37:21 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.