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Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds

Stynes, Gil D., Kiroff, George K., Morrison, Wayne A., Page, Richard S. and Kirkland, Mark A. 2016, Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds, Journal of biomedical materials research, In press, pp. 1-12, doi: 10.1002/jbm.b.33649.

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Title Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds
Author(s) Stynes, Gil D.
Kiroff, George K.
Morrison, Wayne A.
Page, Richard S.ORCID iD for Page, Richard S.
Kirkland, Mark A.
Journal name Journal of biomedical materials research
Season In press
Start page 1
End page 12
Total pages 12
Publisher Wiley
Place of publication Chichester, Eng.
Publication date 2016
ISSN 1552-4981
Keyword(s) cell-material interactions
implant design
implant interface
Summary Avulsion, epidermal marsupialization, and infection cause failure at the skin-material interface. A robust interface would permit implantable robotics, prosthetics, and other medical devices; reconstruction of surgical defects, and long-term access to blood vessels and body cavities. Torus-shaped cap-scaffold structures were designed to work in conjunction with negative pressure to address the three causes of failure. Six wounds were made on the backs of each of four 3-month old pigs. Four unmodified (no caps) scaffolds were implanted along with 20 cap-scaffolds. Collagen type 4 was attached to 21 implants. Negative pressure then was applied. Structures were explanted and assessed histologically at day 7 and day 28. At day 28, there was close tissue apposition to scaffolds, without detectable reactions from defensive or interfering cells. Three cap-scaffolds explanted at day 28 showed likely attachment of epidermis to the cap or cap-scaffold junction, without deeper marsupialization. The combination of toric-shaped cap-scaffolds with negative pressure appears to be an intrinsically biocompatible system, enabling a robust skin-material interface. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.
Language eng
DOI 10.1002/jbm.b.33649
Field of Research 090399 Biomedical Engineering not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Wiley Periodicals
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Document type: Journal Article
Collections: School of Medicine
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