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Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds

Stynes, Gil D., Kiroff, George K., Morrison, Wayne A., Page, Richard S. and Kirkland, Mark A. 2016, Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds, Journal of biomedical materials research, In press, pp. 1-12, doi: 10.1002/jbm.b.33649.

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Title Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds
Author(s) Stynes, Gil D.
Kiroff, George K.
Morrison, Wayne A.
Page, Richard S.ORCID iD for Page, Richard S. orcid.org/0000-0002-2225-7144
Kirkland, Mark A.
Journal name Journal of biomedical materials research
Season In press
Start page 1
End page 12
Total pages 12
Publisher Wiley
Place of publication Chichester, Eng.
Publication date 2016
ISSN 1552-4981
Keyword(s) cell-material interactions
implant design
implant interface
percutaneous
scaffolds
Summary Avulsion, epidermal marsupialization, and infection cause failure at the skin-material interface. A robust interface would permit implantable robotics, prosthetics, and other medical devices; reconstruction of surgical defects, and long-term access to blood vessels and body cavities. Torus-shaped cap-scaffold structures were designed to work in conjunction with negative pressure to address the three causes of failure. Six wounds were made on the backs of each of four 3-month old pigs. Four unmodified (no caps) scaffolds were implanted along with 20 cap-scaffolds. Collagen type 4 was attached to 21 implants. Negative pressure then was applied. Structures were explanted and assessed histologically at day 7 and day 28. At day 28, there was close tissue apposition to scaffolds, without detectable reactions from defensive or interfering cells. Three cap-scaffolds explanted at day 28 showed likely attachment of epidermis to the cap or cap-scaffold junction, without deeper marsupialization. The combination of toric-shaped cap-scaffolds with negative pressure appears to be an intrinsically biocompatible system, enabling a robust skin-material interface. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.
Language eng
DOI 10.1002/jbm.b.33649
Field of Research 090399 Biomedical Engineering not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Wiley Periodicals
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082479

Document type: Journal Article
Collections: School of Medicine
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