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Antiparasitic and immunomodulatory potential of oral nanocapsules encapsulated lactoferrin protein against plasmodium berghei

Anand, Namrata, Kanwar, Rupinder K., Sehgal, Rakesh and Kanwar, Jagat R. 2016, Antiparasitic and immunomodulatory potential of oral nanocapsules encapsulated lactoferrin protein against plasmodium berghei, Nanomedicine, vol. 11, no. 1, pp. 47-62, doi: 10.2217/nnm.15.181.

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Title Antiparasitic and immunomodulatory potential of oral nanocapsules encapsulated lactoferrin protein against plasmodium berghei
Author(s) Anand, Namrata
Kanwar, Rupinder K.
Sehgal, Rakesh
Kanwar, Jagat R.
Journal name Nanomedicine
Volume number 11
Issue number 1
Start page 47
End page 62
Total pages 16
Publisher Future Medicine
Place of publication London, Eng.
Publication date 2016-01
ISSN 1743-5889
1748-6963
Keyword(s) Plasmodium berghei
encapsulation
lactoferrin
miRNA
nanocapsules
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Nanoscience & Nanotechnology
Science & Technology - Other Topics
BOVINE LACTOFERRIN
FALCIPARUM-MALARIA
NUDE-MICE
IRON
NANOCARRIERS
OXIDE
MILK
NANOPARTICLES
NANOMEDICINE
TRANSFERRIN
Summary AIM: To analyze the effect of native buffalo lactoferrin (buLf) protein along with its nanoformulation using alginate-enclosed, chitosan-conjugated, calcium phosphate buffalo Lf nanocapsules (AEC-CCo-CP-buLf NCs) against rodent parasite Plasmodium berghei. MATERIALS & METHODS: BALB/c mice were infected with malaria parasite and efficacy of the proteins (buLf and NCs) was evaluated by measuring parasitemia, initialization, role of miRNA in absorption of NCs, parasite load by histopathology and quantitative determination, cytokine levels, bioavailability and immunohistochemistry to localize Lf protein. RESULTS: NCs significantly reduced the parasite load in mice compared with buLf and untreated group. NCs were found to be modulating the disease profile of mice as shown by immunohistochemistry, free radical ion production and higher survival tendency. CONCLUSION: Our study confirms that NCs internalized and changed the expression of miRNAs that further enhanced their uptake in various organs leading to inhibitory effect against the parasite as well as maintenance of the Fe metabolism.
Language eng
DOI 10.2217/nnm.15.181
Field of Research 1004 Medical Biotechnology
1007 Nanotechnology
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Future Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082601

Document type: Journal Article
Collection: School of Medicine
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