Anxiety, depression and fatigue at 5-year review following CNS demyelination

Simpson, S., Tan, H., Otahal, P., Taylor, B., Ponsonby, A.L., Lucas, R.M., Blizzard, L., Valery, P.C., Lechner-Scott, J., Shaw, C., Williams, D., Ausimmune/AusLong Investigators Group and van der Mei, I. 2016, Anxiety, depression and fatigue at 5-year review following CNS demyelination, Acta neurologica scandinavica, vol. 134, no. 6, pp. 403-413, doi: 10.1111/ane.12554.

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Title Anxiety, depression and fatigue at 5-year review following CNS demyelination
Author(s) Simpson, S.
Tan, H.
Otahal, P.
Taylor, B.
Ponsonby, A.L.
Lucas, R.M.
Blizzard, L.
Valery, P.C.
Lechner-Scott, J.
Shaw, C.ORCID iD for Shaw, C.
Williams, D.
Ausimmune/AusLong Investigators Group
van der Mei, I.
Journal name Acta neurologica scandinavica
Volume number 134
Issue number 6
Start page 403
End page 413
Total pages 11
Publisher John Wiley & Sons
Place of publication London, Eng.
Publication date 2016
ISSN 1600-0404
Keyword(s) multiple sclerosis
first demyelinating event
Ausimmune/AusLong Investigators Group
Summary BACKGROUND: Anxiety and depression are common in multiple sclerosis (MS). We evaluated the prevalence and factors associated with anxiety, depression and fatigue at the 5-year review of a longitudinal cohort study following a first clinical diagnosis of CNS demyelination (FCD).

METHODS: Cases with a FCD were recruited soon after diagnosis and followed annually thereafter. A variety of environmental, behavioural and clinical covariates were measured at five-year review. Anxiety and depression were measured using the Hospital Anxiety & Depression Scale (HADS), and fatigue by the Fatigue Severity Scale (FSS).

RESULTS: Of the 236 cases, 40.2% had clinical anxiety (median HADS-A: 6.0), 16.0% had clinical depression (median HADS-D: 3.0), and 41.3% had clinical fatigue (median FSS: 4.56). The co-occurrence of all three symptoms was 3.76 times greater than expectation. Younger age, higher disability, concussion or other disease diagnosis were independently associated with a higher anxiety score; male sex, higher disability, being unemployed, less physical activity, and antidepressant and/or anxiolytic-sedative medication use were independently associated with a higher depression score. Higher disability, immunomodulatory medication use, other disease diagnosis and anxiolytic-sedative medication use were independently associated with having fatigue, while female sex, higher BMI, having had a concussion, being unemployed and higher disability were associated with a higher fatigue score.

CONCLUSION: These results support previous findings of the commonality of anxiety, depression and fatigue in established MS and extend this to post-FCD and early MS cases. The clustering of the three symptoms indicates that they may share common antecedents.
Language eng
DOI 10.1111/ane.12554
Field of Research 1103 Clinical Sciences
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, John Wiley & Sons
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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