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Aptamers: a promising chemical antibody for cancer therapy

Zhou, Gang, Wilson, George, Hebbard, Lionel, Duan, Wei, Liddle, Christopher, George, Jacob and Qiao, Liang 2016, Aptamers: a promising chemical antibody for cancer therapy, Oncotarget, vol. 7, no. 12, pp. 13446-13463, doi: 10.18632/oncotarget.7178.

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Title Aptamers: a promising chemical antibody for cancer therapy
Author(s) Zhou, Gang
Wilson, George
Hebbard, Lionel
Duan, Wei
Liddle, Christopher
George, Jacob
Qiao, Liang
Journal name Oncotarget
Volume number 7
Issue number 12
Start page 13446
End page 13463
Total pages 18
Publisher Impact Journals
Place of publication Albany, N.Y.
Publication date 2016
ISSN 1949-2553
Keyword(s) SELEX
aptamers
cancers
siRNA
target therapy
Science & Technology
Life Sciences & Biomedicine
Oncology
Cell Biology
TARGETED DRUG-DELIVERY
GROWTH-FACTOR RECEPTOR
RENAL-CELL CARCINOMA
RNA APTAMER
IN-VIVO
TUMOR-CELLS
DNA-APTAMER
HIGH-AFFINITY
OLIGONUCLEOTIDE APTAMERS
4-1BB COSTIMULATION
Summary Aptamers, also known as chemical antibodies, are single-stranded nucleic acid oligonucleotides which bind to their targets with high specificity and affinity. They are typically selected by repetitive in vitro process termed systematic evolution of ligands by exponential enrichment (SELEX). Owing to their excellent properties compared to conventional antibodies, notably their smaller physical size and lower immunogenicity and toxicity, aptamers have recently emerged as a new class of agents to deliver therapeutic drugs to cancer cells by targeting specific cancer-associated hallmarks. Aptamers can also be structurally modified to make them more flexible in order to conjugate other agents such as nano-materials and therapeutic RNA agents, thus extending their applications for cancer therapy. This review presents the current knowledge on the practical applications of aptamers in the treatment of a variety of cancers.
Language eng
DOI 10.18632/oncotarget.7178
Field of Research 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Impact Journals LLC
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082603

Document type: Journal Article
Collection: School of Medicine
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