This project examined the impact of pegylation on secondary structure of insulin during tablet making process and assessed the metabolism in in-vitro and in-vivo model. It was found that pegylation per se does not affect the secondary structure of insulin. The tablet making process did not have any impact on the pegylated insulin structure. In the in vitro model and in vivo model, pegylated lysine and free peg molecule were found to be the metabolites specific to pegylated insulin.
Field of Research
100306 Industrial Molecular Engineering of Nucleic Acids and Proteins 100403 Medical Molecular Engineering of Nucleic Acids and Proteins
Socio Economic Objective
Description of original
201 pages : illustrations, tables, graphs, some coloured
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