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Development and evaluation of a novel insulin analogue

Khedkar, Anand 2015, Development and evaluation of a novel insulin analogue, PhD thesis, School of Life and Environmental Sciences, Deakin Univeristy.

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Title Development and evaluation of a novel insulin analogue
Author Khedkar, Anand
Institution Deakin Univeristy
School School of Life and Environmental Sciences
Faculty Faculty of Science, Engineering and Built Environment
Degree type Research doctorate
Degree name PhD
Thesis advisor Barrow, Colin
Sastry, Kedarnath
Date submitted 2015-02
Keyword(s) diabetes
insulin delivery
oral delivery
Summary  This project examined the impact of pegylation on secondary structure of insulin during tablet making process and assessed the metabolism in in-vitro and in-vivo model. It was found that pegylation per se does not affect the secondary structure of insulin. The tablet making process did not have any impact on the pegylated insulin structure. In the in vitro model and in vivo model, pegylated lysine and free peg molecule were found to be the metabolites specific to pegylated insulin.
Language eng
Field of Research 100306 Industrial Molecular Engineering of Nucleic Acids and Proteins
100403 Medical Molecular Engineering of Nucleic Acids and Proteins
Socio Economic Objective 920104 Diabetes
Description of original 201 pages : illustrations, tables, graphs, some coloured
Dewey Decimal Classification 616.46206
Restricted until 2016-12-31
Copyright notice ┬ęThe author
Free to Read? No
Free to Read Start Date 2016-12-31
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082751

Document type: Thesis
Collection: Higher degree theses (citation only)
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Created: Tue, 12 Apr 2016, 10:13:49 EST by Kate Percival

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