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Clinical performance of three silicone hydrogel daily disposable lenses

Varikooty, Jalaiah, Schulze, Marc M., Dumbleton, Kathy, Keir, Nancy, Woods, Craig A., Fonn, Desmond and Jones, Lyndon W. 2015, Clinical performance of three silicone hydrogel daily disposable lenses, Optometry and vision science, vol. 92, no. 3, pp. 301-311, doi: 10.1097/OPX.0000000000000514.

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Title Clinical performance of three silicone hydrogel daily disposable lenses
Author(s) Varikooty, Jalaiah
Schulze, Marc M.
Dumbleton, Kathy
Keir, Nancy
Woods, Craig A.ORCID iD for Woods, Craig A. orcid.org/0000-0002-5942-6247
Fonn, Desmond
Jones, Lyndon W.
Journal name Optometry and vision science
Volume number 92
Issue number 3
Start page 301
End page 311
Total pages 11
Publisher Lippincott Williams & Wilkins
Place of publication Hagerstown, Md.
Publication date 2015-03
ISSN 1040-5488
Summary Purpose: To determine the clinical performance of DAILIES TOTAL1 (DT1), Clariti 1Day (C1D), and 1-DAY ACUVUE TruEye (AVTE) silicone hydrogel daily disposable contact lenses (SiHy DDCLs).

Methods: Eligible participants, subdivided into asymptomatic and symptomatic groups, wore each SiHy DDCLs for three consecutive days. Each participant attended three visits (on day 1 at 0 hours; on days 1 and 3 after 8 hours of wear) per lens type. The order of lens wear was randomized, with at least 1 day washout between lenses. Lens-related performance was evaluated by assessing lens surface deposits, wettability, pre-lens noninvasive tear breakup time, lens movement, and centration; ocular response assessments included conjunctival redness, corneal staining, and conjunctival staining and indentation.

Results: Fifty-one asymptomatic and 53 symptomatic participants completed the study. For all visits, the mean noninvasive tear breakup time was about 1 second longer with DT1 than with C1D and AVTE (p < 0.01). Overall, the wettability of all three lenses was good; however, DT1 was graded marginally better than the other lenses (both p < 0.01). On day 3, eyes wearing AVTE had significantly more dehydration-induced corneal staining compared with DT1 (AVTE, 24%; DT1, 11%; p < 0.01). After 8 hours, conjunctival staining was different between lenses (greatest with C1D and least with DT1; all p < 0.01). Conjunctival indentation was more prevalent with the C1D lenses (n = 70) compared with DT1 (n = 1; p < 0.01) and AVTE (n = 11; p < 0.01). There were no differences between asymptomatic and symptomatic lens wearers for any of the clinical parameters (all p > 0.05).

Conclusions: Each of the three SiHy DDCLs performed well. Noninvasive tear breakup time was longest and wettability was greater with DT1. C1D had the most conjunctival staining conjunctival indentation. There was no difference between asymptomatic and symptomatic wearers with regard to ocular response and contact lens–related parameters. These results suggest that SiHy DDCLs may be an excellent contact lens modality for the symptomatic patient
Language eng
DOI 10.1097/OPX.0000000000000514
Field of Research 111399 Ophthalmology and Optometry not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082937

Document type: Journal Article
Collection: School of Medicine
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