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Coupling hydrophilic amine-containing molecules to the backbone of poly(ε-caprolactone)

Prime, Emma L., Cooper-White, Justin J. and Qiao, Greg G. 2006, Coupling hydrophilic amine-containing molecules to the backbone of poly(ε-caprolactone), Australian journal of chemistry, vol. 59, no. 8, pp. 534-538, doi: 10.1071/CH06144.

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Title Coupling hydrophilic amine-containing molecules to the backbone of poly(ε-caprolactone)
Formatted title Coupling hydrophilic amine-containing molecules to the backbone of poly(ε-caprolactone)
Author(s) Prime, Emma L.ORCID iD for Prime, Emma L. orcid.org/0000-0002-1410-6717
Cooper-White, Justin J.
Qiao, Greg G.
Journal name Australian journal of chemistry
Volume number 59
Issue number 8
Start page 534
End page 538
Total pages 5
Publisher CSIRO Publishing
Place of publication Clayton, Vic.
Publication date 2006-09-18
ISSN 0004-9425
1445-0038
Summary A poly(ε-caprolactone) (PCL) based biodegradable polymer containing robust, amine-reactive side chains has been successfully synthesized. The specific reactivity of the side chains allows for the coupling of unmodified amine-containing molecules such as poly(l-lysine) (PLL) to PCL to occur in the presence of other unprotected functional groups. The reactivity of this polymer has been demonstrated through successful coupling of both benzylamine (a model compound) and PLL. This novel amine-reactive polymer could have numerous applications in biomedical fields such as tissue engineering and drug delivery.
Language eng
DOI 10.1071/CH06144
Field of Research 030306 Synthesis of Materials
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
Copyright notice ©2006, CSIRO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082944

Document type: Journal Article
Collection: Institute for Frontier Materials
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