Addition of biological functionality to poly(epsilon-caprolactone) films

Prime, Emma L., Hamid, Zuratul Ain Abdul, Cooper-White, Justin J. and Qiao, Greg G. 2007, Addition of biological functionality to poly(epsilon-caprolactone) films, Biomacromolecules, vol. 8, no. 8, pp. 2416-2421, doi: 10.1021/bm0702962.

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Title Addition of biological functionality to poly(epsilon-caprolactone) films
Author(s) Prime, Emma L.ORCID iD for Prime, Emma L.
Hamid, Zuratul Ain Abdul
Cooper-White, Justin J.
Qiao, Greg G.
Journal name Biomacromolecules
Volume number 8
Issue number 8
Start page 2416
End page 2421
Total pages 6
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2007
ISSN 1525-7797
Summary Biodegradable polyesters such as poly(epsilon-caprolactone) (PCL) have a number of biomedical applications; however, their usage is often limited by a lack of biological functionality. In this paper, a PCL-based polymer containing pendent groups activated by 4-nitrophenyl chloroformate (NPC) and reactive toward primary amines has been cast into thin films. The reactivity of the films toward poly(l-lysine) and the cell adhesion peptide, GRGDS, was assessed, and their cell adhesive capabilities were characterized. ATR-FTIR analysis found that NPC functional groups were present on the surface of the cast film, and the synthesis, conjugation, and visualization of a fluorescent molecule on these films further demonstrated the success of this functionalization methodology. The immersion of these films into a solution of either poly(l-lysine) (PLL) or GRGDS in PBS (pH 7.4) and subsequent 3T3 fibroblast adhesion studies demonstrated significant improvement in cell adhesion and spreading over films cast from unmodified PCL. This investigation has shown that this novel NPC-containing polymer can be utilized in many applications where increased cellular adhesion is required, or the coupling of specific molecules to polymer surfaces is of interest.
Language eng
DOI 10.1021/bm0702962
Field of Research 030306 Synthesis of Materials
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
Copyright notice ©2007, American Chemical Society
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