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Conjugation of bioactive groups to poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)] films

Prime, Emma L., Cooper-White, Justin J. and Qiao, Greg G. 2007, Conjugation of bioactive groups to poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)] films, Macromolecular bioscience, vol. 7, no. 12, pp. 1272-1279, doi: 10.1002/mabi.200700153.

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Title Conjugation of bioactive groups to poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)] films
Author(s) Prime, Emma L.ORCID iD for Prime, Emma L. orcid.org/0000-0002-1410-6717
Cooper-White, Justin J.
Qiao, Greg G.
Journal name Macromolecular bioscience
Volume number 7
Issue number 12
Start page 1272
End page 1279
Total pages 8
Publisher Wiley-VCH
Place of publication Weinheim, Germany
Publication date 2007-12-06
ISSN 1616-5187
1616-5195
Summary A novel PLA-based polymer containing reactive pendent ketone or hydroxyl groups was synthesized by the copolymerization of L-lactide with epsilon-caprolactone-based monomers. The polymer was activated with NPC, resulting in an amine-reactive polymer which was then cast into thin polymeric films, either alone or as part of a blend with PLGA, before immersion into a solution of the cell adhesion peptide GRGDS in PBS buffer allowed for conjugation of GRGDS to the film surfaces. Subsequent 3T3 fibroblast cell adhesion studies demonstrated an increase in cellular adhesion and spreading over films cast from unmodified PLGA. Hence the new polymer can be used to obtain covalent linkage of amine-containing molecules to polymer surfaces.
Language eng
DOI 10.1002/mabi.200700153
Field of Research 030306 Synthesis of Materials
0303 Macromolecular And Materials Chemistry
0903 Biomedical Engineering
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
Copyright notice ©2007, Wiley-VCH
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082953

Document type: Journal Article
Collection: Institute for Frontier Materials
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