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Changes in oxygenation in mechanically ventilated critically ill patients following hyperbaric treatment

Bingham, Gordon, Millar, Ian, Koch, Susan, Eldho, Paul, Varma, Dinesh and Pilcher, David 2011, Changes in oxygenation in mechanically ventilated critically ill patients following hyperbaric treatment, Diving and hyperbaric medicine, vol. 41, no. 2, pp. 59-63.

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Title Changes in oxygenation in mechanically ventilated critically ill patients following hyperbaric treatment
Author(s) Bingham, Gordon
Millar, Ian
Koch, Susan
Eldho, Paul
Varma, Dinesh
Pilcher, David
Journal name Diving and hyperbaric medicine
Volume number 41
Issue number 2
Start page 59
End page 63
Total pages 5
Publisher South Pacific Underwater Medicine Society
Place of publication Melbourne, Vic.
Publication date 2011-06
ISSN 1833-3516
Summary BACKGROUND: Some ventilated intensive care unit (ICU) patients may experience reduced oxygenation following hyperbaric oxygen treatment (HBOT).

METHODS: In a prospective, single-centre, observational study, we documented changes in oxygenation and the need for associated changes in ventilator settings in 25 consecutive, mechanically ventilated ICU patients immediately post-treatment and 1, 2, 3 and 6 hours following 61 HBOT sessions. The primary outcome measure of oxygenation was the ratio of arterial partial pressure of oxygen (P(a)O2) against the level of inspired oxygen (F(i)O2), P(a)O2/F(i)O2.

RESULTS: Following HBOT, the P(a)O2/F(i)O2 ratio decreased by 27% on return to ICU (P < 0.001, 95% confidence intervals (CI) 20.6 to 34.2); 22% at 1 hour post-HBOT (P < 0.001, 95% CI 15.1 to 28.6); and 8% at 2 hours post (P = 0.03, 95% CI 0.8 to 14.4). The ratio showed no significant differences from pre-HBOT at 3 and 6 hours post-HBOT. P(a)O2/F(i)O2 ratio changes necessitated adjustments to ventilation parameters upon return to ICU following 30 of 61 HBOT sessions in 17 out of the 25 patients. The most common ventilation parameter altered was F(i)O2 (n = 20), increased by a mean of +0.17 (95% CI 0.11 to 0.23) above baseline for two hours following HBOT.

CONCLUSIONS: Following HBOT, oxygenation is reduced in a majority of mechanically ventilated ICU patients and requires temporary alterations to mechanical ventilation settings. Further study to identify predictive characteristics and to determine causation for those at risk of needing ventilation alterations is required.
Language eng
Field of Research 111099 Nursing not elsewhere classified
Socio Economic Objective 920210 Nursing
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, South Pacific Underwater Medicine Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082984

Document type: Journal Article
Collection: School of Nursing and Midwifery
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