Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study

Livingstone, Katherine M., Celis-Morales, Carlos, Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Forster, Hannah, O'Donovan, Clare B., Woolhead, Clara, Marsaux, Cyril F. M., Macready, Anna L., Fallaize, Rosalind, Kolossa, Silvia, Tsirigoti, Lydia, Lambrinou, Christina P., Moschonis, George, Godlewska, Magdalena, Surwiłło, Agnieszka, Drevon, Christian A., Manios, Yannis, Traczyk, Iwona, Gibney, Eileen R., Brennan, Lorraine, Walsh, Marianne C., Lovegrove, Julie A., Martinez, J. Alfredo, Saris, Wim H. M., Daniel, Hannelore, Gibney, Mike and Mathers, John C. 2016, Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study, The British journal of nutrition, vol. 115, no. 3, pp. 440-448, doi: 10.1017/S0007114515004675.

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Title Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study
Author(s) Livingstone, Katherine M.ORCID iD for Livingstone, Katherine M. orcid.org/0000-0002-9682-7541
Celis-Morales, Carlos
Navas-Carretero, Santiago
San-Cristobal, Rodrigo
Forster, Hannah
O'Donovan, Clare B.
Woolhead, Clara
Marsaux, Cyril F. M.
Macready, Anna L.
Fallaize, Rosalind
Kolossa, Silvia
Tsirigoti, Lydia
Lambrinou, Christina P.
Moschonis, George
Godlewska, Magdalena
Surwiłło, Agnieszka
Drevon, Christian A.
Manios, Yannis
Traczyk, Iwona
Gibney, Eileen R.
Brennan, Lorraine
Walsh, Marianne C.
Lovegrove, Julie A.
Martinez, J. Alfredo
Saris, Wim H. M.
Daniel, Hannelore
Gibney, Mike
Mathers, John C.
Journal name The British journal of nutrition
Volume number 115
Issue number 3
Start page 440
End page 448
Total pages 9
Publisher Cambridge University Press
Place of publication London, Eng.
Publication date 2016-02
ISSN 1475-2662
Keyword(s) BMI
Dietary intakes
EI total energy intake
FTO fat mass- and obesity-associated gene
Fat mass- and obesity-associated gene
Fried foods
MD PREDIMED-based Mediterranean diet score
PA physical activity
RCT randomised controlled trial
WC waist circumference
Adipose Tissue
Aged, 80 and over
Body Mass Index
Energy Intake
European Continental Ancestry Group
Food Habits
Gene-Environment Interaction
Genetic Predisposition to Disease
Genetic Variation
Life Style
Middle Aged
Surveys and Questionnaires
Waist Circumference
Food4Me study
Summary The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1·4 kg/m2 greater BMI (Ptrend=0·028) and 3·1 cm greater WC (Ptrend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.
Language eng
DOI 10.1017/S0007114515004675
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
0702 Animal Production
1111 Nutrition And Dietetics
0908 Food Sciences
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30082993

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