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Is fatty acid intake a predictor of arterial stiffness and blood pressure in men? Evidence from the Caerphilly Prospective Study

Livingstone, K. M., Givens, D. I., Cockcroft, J. R., Pickering, J. E. and Lovegrove, J. A. 2013, Is fatty acid intake a predictor of arterial stiffness and blood pressure in men? Evidence from the Caerphilly Prospective Study, Nutrition, metabolism and cardiovascular diseases, vol. 23, no. 11, pp. 1079-1085, doi: 10.1016/j.numecd.2012.12.002.

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Title Is fatty acid intake a predictor of arterial stiffness and blood pressure in men? Evidence from the Caerphilly Prospective Study
Author(s) Livingstone, K. M.ORCID iD for Livingstone, K. M. orcid.org/0000-0002-9682-7541
Givens, D. I.
Cockcroft, J. R.
Pickering, J. E.
Lovegrove, J. A.
Journal name Nutrition, metabolism and cardiovascular diseases
Volume number 23
Issue number 11
Start page 1079
End page 1085
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-11
ISSN 1590-3729
Keyword(s) AIx
Arterial stiffness
Blood pressure
CVD
Cardiovascular disease
DBP
Fatty acids
HDL
LDL
MUFA
PUFA
Pulse wave velocity
SBP
SFA
aPWV
aortic pulse wave velocity
augmentation index
diastolic blood pressure
high-density lipoprotein
low-density lipoprotein
mono-unsaturated fatty acids
poly-unsaturated fatty acids
saturated fatty acids
systolic blood pressure
Aorta
Biomarkers
Cardiovascular Diseases
Cross-Sectional Studies
Dietary Fats
Disease Progression
Fatty Acids, Unsaturated
Humans
Hypertension
Inflammation Mediators
Longitudinal Studies
Lost to Follow-Up
Male
Middle Aged
Prospective Studies
Pulse Wave Analysis
Risk Factors
Vascular Stiffness
Wales
Summary BACKGROUND AND AIMS: Arterial stiffness is an independent predictor of cardiovascular disease (CVD) events and all-cause mortality and may be differentially affected by dietary fatty acid (FA) intake. The aim of this study was to investigate the relationship between FA consumption and arterial stiffness and blood pressure in a community-based population.
METHODS AND RESULTS: The Caerphilly Prospective Study recruited 2398 men, aged 45-59 years, who were followed up at 5-year intervals for a mean of 17.8-years (n 787). A semi-quantitative food frequency questionnaire estimated intakes of total, saturated, mono- and poly-unsaturated fatty acids (SFA, MUFA, PUFA). Multiple regression models investigated associations between intakes of FA at baseline with aortic pulse wave velocity (aPWV), augmentation index (AIx), systolic and diastolic blood pressure (SBP, DBP) and pulse pressure after a 17.8-year follow-up--as well as cross-sectional relationships with metabolic markers. After adjustment, higher SFA consumption at baseline was associated with higher SBP (P = 0.043) and DBP (P = 0.002) and after a 17.8-year follow-up was associated with a 0.51 m/s higher aPWV (P = 0.006). After adjustment, higher PUFA consumption at baseline was associated with lower SBP (P = 0.022) and DBP (P = 0.036) and after a 17.8-year follow-up was associated with a 0.63 m/s lower aPWV (P = 0.007).
CONCLUSION: This study suggests that consumption of SFA and PUFA have opposing effects on arterial stiffness and blood pressure. Importantly, this study suggests that consumption of FA is an important risk factor for arterial stiffness and CVD.
Language eng
DOI 10.1016/j.numecd.2012.12.002
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Elsevier B.V
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083003

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