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Changes in physical activity following a genetic-based internet-delivered personalized intervention: randomized controlled trial (Food4Me)

Marsaux, Cyril F. M., Celis-Morales, Carlos, Livingstone, Katherine M., Fallaize, Rosalind, Kolossa, Silvia, Hallmann, Jacqueline, San-Cristobal, Rodrigo, Navas-Carretero, Santiago, O'Donovan, Clare B., Woolhead, Clara, Forster, Hannah, Moschonis, George, Lambrinou, Christina-Paulina, Surwillo, Agnieszka, Godlewska, Magdalena, Hoonhout, Jettie, Goris, Annelies, Macready, Anna L., Walsh, Marianne C., Gibney, Eileen R., Brennan, Lorraine, Manios, Yannis, Traczyk, Iwona, Drevon, Christian A., Lovegrove, Julie A., Martinez, J. Alfredo, Danie, Hannelore, Gibney, Michael J., Mathers, John C. and Saris, Wim H. M. 2016, Changes in physical activity following a genetic-based internet-delivered personalized intervention: randomized controlled trial (Food4Me), Journal of medical internet research, vol. 18, no. 2, pp. 1-15, doi: 10.2196/jmir.5198.

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Title Changes in physical activity following a genetic-based internet-delivered personalized intervention: randomized controlled trial (Food4Me)
Author(s) Marsaux, Cyril F. M.
Celis-Morales, Carlos
Livingstone, Katherine M.
Fallaize, Rosalind
Kolossa, Silvia
Hallmann, Jacqueline
San-Cristobal, Rodrigo
Navas-Carretero, Santiago
O'Donovan, Clare B.
Woolhead, Clara
Forster, Hannah
Moschonis, George
Lambrinou, Christina-Paulina
Surwillo, Agnieszka
Godlewska, Magdalena
Hoonhout, Jettie
Goris, Annelies
Macready, Anna L.
Walsh, Marianne C.
Gibney, Eileen R.
Brennan, Lorraine
Manios, Yannis
Traczyk, Iwona
Drevon, Christian A.
Lovegrove, Julie A.
Martinez, J. Alfredo
Danie, Hannelore
Gibney, Michael J.
Mathers, John C.
Saris, Wim H. M.
Journal name Journal of medical internet research
Volume number 18
Issue number 2
Start page 1
End page 15
Total pages 15
Publisher JMIR Publications
Place of publication Toronto, Ont.
Publication date 2016-02-05
ISSN 1438-8871
Summary Background: There is evidence that physical activity (PA) can attenuate the influence of the fat mass- and obesity-associated (FTO) genotype on the risk to develop obesity. However, whether providing personalized information on FTO genotype leads to changes in PA is unknown. Objective: The purpose of this study was to determine if disclosing FTO risk had an impact on change in PA following a 6-month intervention.

Methods: The single nucleotide polymorphism (SNP) rs9939609 in the FTO gene was genotyped in 1279 participants of the Food4Me study, a four-arm, Web-based randomized controlled trial (RCT) in 7 European countries on the effects of personalized advice on nutrition and PA. PA was measured objectively using a TracmorD accelerometer and was self-reported using the Baecke questionnaire at baseline and 6 months. Differences in baseline PA variables between risk (AA and AT genotypes) and nonrisk (TT genotype) carriers were tested using multiple linear regression. Impact of FTO risk disclosure on PA change at 6 months was assessed among participants with inadequate PA, by including an interaction term in the model: disclosure (yes/no) × FTO risk (yes/no).

Results: At baseline, data on PA were available for 874 and 405 participants with the risk and nonrisk FTO genotypes, respectively. There were no significant differences in objectively measured or self-reported baseline PA between risk and nonrisk carriers. A total of 807 (72.05%) of the participants out of 1120 in the personalized groups were encouraged to increase PA at baseline. Knowledge of FTO risk had no impact on PA in either risk or nonrisk carriers after the 6-month intervention. Attrition was higher in nonrisk participants for whom genotype was disclosed (P=.01) compared with their at-risk counterparts.

Conclusions: No association between baseline PA and FTO risk genotype was observed. There was no added benefit of disclosing FTO risk on changes in PA in this personalized intervention. Further RCT studies are warranted to confirm whether disclosure of nonrisk genetic test results has adverse effects on engagement in behavior change.
Language eng
DOI 10.2196/jmir.5198
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083032

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.