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A novel and facile approach to fabricate a conductive and biomimetic fibrous platform with sub-micron and micron features

Esrafilzadeh, Dorna, Jalili, Rohoullah, Liu, Xiao, Gilmore, Kerry J., Razal, Joselito M., Moulton, Simon E. and Wallace, Gordon G. 2016, A novel and facile approach to fabricate a conductive and biomimetic fibrous platform with sub-micron and micron features, Journal of materials chemistry B, vol. 4, no. 6, pp. 1056-1063, doi: 10.1039/c5tb02237a.

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Title A novel and facile approach to fabricate a conductive and biomimetic fibrous platform with sub-micron and micron features
Author(s) Esrafilzadeh, Dorna
Jalili, Rohoullah
Liu, Xiao
Gilmore, Kerry J.
Razal, Joselito M.
Moulton, Simon E.
Wallace, Gordon G.
Journal name Journal of materials chemistry B
Volume number 4
Issue number 6
Start page 1056
End page 1063
Total pages 8
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2016-02-14
ISSN 2050-7518
2050-750X
Summary The demands of multifunctional scaffolds have exceeded the passive biocompatible properties previously considered sufficient for tissue engineering. Herein, a novel and facile method used to fabricate a core-shell structure consisting of a conducting fiber core and an electrospun fiber shell is presented. This multifunctional structure simultaneously provides the high conductivity of conducting polymers as well as the enhanced interactions between cells and the sub-micron topographical environments provided by highly aligned cytocompatible electrospun fibers. Unlimited lengths of PEDOT:PSS-Chitosan-PLGA fibers loaded with an antibiotic drug, ciprofloxacin hydrochloride, were produced using this method. The fibers provide modulated drug release with excellent mechanical properties, electrochemical performance and cytocompatibility, which hold great promise for the application of conductive electrospun scaffolds in regenerative medicine.
Language eng
DOI 10.1039/c5tb02237a
Field of Research 091012 Textile Technology
091202 Composite and Hybrid Materials
100708 Nanomaterials
Socio Economic Objective 860406 Synthetic Fibres
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID FT130100380
Copyright notice ©2016, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083079

Document type: Journal Article
Collection: Institute for Frontier Materials
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Created: Wed, 27 Apr 2016, 09:09:14 EST

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