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Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements

Kendall, Megan, Batterham, Marijka, Callahan, Damien L., Jardine, Daniel, Prenzler, Paul D., Robards, Kevin and Ryan, Danielle 2012, Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements, Food chemistry, vol. 130, no. 3, pp. 651-659, doi: 10.1016/j.foodchem.2011.07.101.

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Title Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements
Author(s) Kendall, Megan
Batterham, Marijka
Callahan, Damien L.ORCID iD for Callahan, Damien L. orcid.org/0000-0002-6384-8717
Jardine, Daniel
Prenzler, Paul D.
Robards, Kevin
Ryan, Danielle
Journal name Food chemistry
Volume number 130
Issue number 3
Start page 651
End page 659
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2012-02-01
ISSN 0308-8146
Keyword(s) Adults
excretion
healthy
Oleuropein
urine
Summary Olive leaf supplement was characterised by HPLC and administered to healthy young adults over 28 d (three tablets or equivalent liquid dose per day), or in a single bolus dose of three tablets (or liquid equivalent). Oleuropein was the major biophenol in the extracts. There are no data on the excretion of urinary end-products of the metabolism of the olive leaf biophenols. Following both chronic and acute ingestion neither oleuropein, nor its hydrolysis product, hydroxytyrosol, were detected in urine samples. However, glucuronic acid conjugates, derived from oleuropein aglycone were detected in all urine samples up to 6 h following acute ingestion. The data suggest that oleuropein is bioavailable, which is a necessary pre-condition for bioactivity.
Language eng
DOI 10.1016/j.foodchem.2011.07.101
Field of Research 030101 Analytical Spectrometry
110199 Medical Biochemistry and Metabolomics not elsewhere classified
MD Multidisciplinary
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083097

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