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Cross-fostering reduces obesity induced by early exposure to monosodium glutamate in male rats

Miranda, Rosiane A., da Silva Franco, Claudineia C., de Oliveira, Julio C., Barella, Luiz F., Tófolo, Laize P., Ribeiro, Tatiane A., Pavanello, Audrei, da Conceição, Ellen P. S., Torrezan, Rosana, Armitage, James, Lisboa, Patricia C., de Moura, Egberto G., de Freitas Mathias, Paulo C. and Vieira, Elaine 2017, Cross-fostering reduces obesity induced by early exposure to monosodium glutamate in male rats, Endocrine, vol. 55, no. 1, pp. 101-112, doi: 10.1007/s12020-016-0965-y.

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Title Cross-fostering reduces obesity induced by early exposure to monosodium glutamate in male rats
Author(s) Miranda, Rosiane A.
da Silva Franco, Claudineia C.
de Oliveira, Julio C.
Barella, Luiz F.
Tófolo, Laize P.
Ribeiro, Tatiane A.
Pavanello, Audrei
da Conceição, Ellen P. S.
Torrezan, Rosana
Armitage, James
Lisboa, Patricia C.
de Moura, Egberto G.
de Freitas Mathias, Paulo C.
Vieira, Elaine
Journal name Endocrine
Volume number 55
Issue number 1
Start page 101
End page 112
Total pages 12
Publisher Springer
Place of publication New York, N.Y.
Publication date 2017-01
ISSN 1559-0100
Keyword(s) cross-fostering
monosodium glutamate
obesity
Summary Maternal obesity programmes a range of metabolic disturbances for the offspring later in life. Moreover, environmental changes during the suckling period can influence offspring development. Because both periods significantly affect long-term metabolism, we aimed to study whether cross-fostering during the lactation period was sufficient to rescue a programmed obese phenotype in offspring induced by maternal obesity following monosodium L-glutamate (MSG) treatment. Obesity was induced in female Wistar rats by administering subcutaneous MSG (4 mg/g body weight) for the first 5 days of postnatal life. Control and obese female rats were mated in adulthood. The resultant pups were divided into control second generation (F2) (CTLF2), MSG-treated second generation (F2) (MSGF2), which suckled from their CTL and MSG biological dams, respectively, or CTLF2-CR, control offspring suckled by MSG dams and MSGF2-CR, MSG offspring suckled by CTL dams. At 120 days of age, fat tissue accumulation, lipid profile, hypothalamic leptin signalling, glucose tolerance, glucose-induced, and adrenergic inhibition of insulin secretion in isolated pancreatic islets were analysed. Maternal MSG-induced obesity led to an obese phenotype in male offspring, characterized by hyperinsulinaemia, hyperglycaemia, hyperleptinaemia, dyslipidaemia, and impaired leptin signalling, suggesting central leptin resistance, glucose intolerance, impaired glucose-stimulated, and adrenergic inhibition of insulin secretion. Cross-fostering normalized body weight, food intake, leptin signalling, lipid profiles, and insulinaemia, but not glucose homeostasis or insulin secretion from isolated pancreatic islets. Our findings suggest that alterations during the lactation period can mitigate the development of obesity and prevent the programming of adult diseases.
Language eng
DOI 10.1007/s12020-016-0965-y
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
111401 Foetal Development and Medicine
110306 Endocrinology
1103 Clinical Sciences
1114 Paediatrics And Reproductive Medicine
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Springer Science+Business Media New York
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083181

Document type: Journal Article
Collection: School of Medicine
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