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Cytokine networks and cancer stem cells

Liongue, Clifford, Ward, Alister C., Duan, Wei and Shigdar, Sarah 2015, Cytokine networks and cancer stem cells. In Babashah, S. (ed), Cancer stem cells : emerging concepts and future perspectives in translational oncology, Springer, Berlin, Germany, pp.67-87, doi: 10.1007/978-3-319-21030-8_3.

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Title Cytokine networks and cancer stem cells
Author(s) Liongue, Clifford
Ward, Alister C.ORCID iD for Ward, Alister C. orcid.org/0000-0001-7945-7975
Duan, Wei
Shigdar, Sarah
Title of book Cancer stem cells : emerging concepts and future perspectives in translational oncology
Editor(s) Babashah, S.
Publication date 2015
Chapter number 3
Total chapters 19
Start page 67
End page 87
Total pages 21
Publisher Springer
Place of Publication Berlin, Germany
Keyword(s) Cancer
cancer stem cells
cytokines
inflammation
signaling networks
Summary Cell-to-cell communication is an integral function of multicellular organisms. Many of these signals are received by a myriad of cell-surface receptors that utilize a range of intracellular signaling pathways to communicate this to the nucleus, rapidly impacting on the transcription of target genes in order to elicit the desired response, such as proliferation, differentiation, activation, and survival. Dysregulation of these important signaling pathways, and networks, often lead to pathological conditions due to inappropriate cell responses with negative consequences. The aberrant signaling pathways have been associated with many diseases, including cancer. Cytokines and chemokines convey a multitude of messages to the target cell, many of which are beneficial for cancers and cancer stem cells, such as proliferation, survival and migration. By hijacking this communication network, cancers and cancer stem cells can become invasive and more pathogenic. Furthermore, by using these communication systems, cancer stem cells are able to evade current therapies. Therefore, novel therapies may be developed to break the communication systems of the cancer stem cells. This chapter explores the role of the cytokines TGF-β, TNF-α, IL-1 and IL-6 and chemokine CXCL8 as well as NF-κB and their role in cancer stem cell survival and maintenance. Emerging therapies are beginning to target the cancer stem cell population, either specifically or synergistically with existing therapeutic options. These novel therapies may hold the key to breaking the communication network of cancer stem cells.
ISBN 9783319210292
3319210300
Language eng
DOI 10.1007/978-3-319-21030-8_3
Field of Research 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category B1 Book chapter
ERA Research output type B Book chapter
Copyright notice ©2015, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083201

Document type: Book Chapter
Collections: Open Access Collection
Molecular and Medical Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.