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Signaling via the CytoR/JAK/STAT/SOCS pathway: emergence during evolution

Liongue, Clifford, Taznin, Tarannum and Ward, Alister C. 2016, Signaling via the CytoR/JAK/STAT/SOCS pathway: emergence during evolution, Molecular immunology, vol. 71, pp. 166-175, doi: 10.1016/j.molimm.2016.02.002.

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Title Signaling via the CytoR/JAK/STAT/SOCS pathway: emergence during evolution
Author(s) Liongue, CliffordORCID iD for Liongue, Clifford orcid.org/0000-0002-1646-4905
Taznin, Tarannum
Ward, Alister C.ORCID iD for Ward, Alister C. orcid.org/0000-0001-7945-7975
Journal name Molecular immunology
Volume number 71
Start page 166
End page 175
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-03
ISSN 1872-9142
Keyword(s) Cytokine receptor
Evolution
JAK
SOCS
STAT
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Immunology
COLONY-STIMULATING FACTOR
JAK-STAT
JAK/STAT PATHWAY
SOCS PROTEINS
NEGATIVE REGULATION
CYTOKINE RECEPTORS
IMMUNE-RESPONSES
STRUCTURAL BASIS
TYROSINE KINASE
DROSOPHILA
Summary Cell-cell signaling represents an essential hallmark of multicellular organisms, which necessarily require a means of communicating between different cell populations, particularly immune cells. Cytokine receptor signaling through the Janus kinase/Signal Transducer and Activator of Transcription/Suppressor of Cytokine Signaling (CytoR/JAK/STAT/SOCS) pathway embodies one important paradigm by which this is achieved. This pathway has been extensively studied in vertebrates and protostomes and shown to play fundamental roles in development and function of immune and other cells. However, our understanding of the origins of the individual pathway components and their assembly into a functional pathway has remained limited. This study examined the origins of each component of this pathway through bioinformatics analysis of key extant species. This has revealed step-wise accretion of individual components over a large evolutionary time-frame, but only in bilateria did a series of innovations allow their final coalescence to form a complete pathway. Assembly of the CytoR/JAK/STAT pathway has followed the retrograde model of pathway evolution, whereas addition of the SOCS component has adhered to the patchwork model.
Language eng
DOI 10.1016/j.molimm.2016.02.002
Field of Research 1107 Immunology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083204

Document type: Journal Article
Collection: School of Medicine
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