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Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis

She, Xiaodong, Chen, Lijue, Yi, Zhifeng, Li, Chengpeng, He, Canzhong, Feng, Chunfang, Wang, Tao, Shigdar, Sarah, Duan, Wei and Kong, Lingxue 2016, Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis, Mini-reviews in medicinal chemistry, vol. 16, no. Mini-reviews issue, pp. 1-40, doi: 10.2174/1389557516666160505114814.

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Title Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis
Author(s) She, Xiaodong
Chen, Lijue
Yi, Zhifeng
Li, Chengpeng
He, Canzhong
Feng, Chunfang
Wang, Tao
Shigdar, Sarah
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Kong, LingxueORCID iD for Kong, Lingxue orcid.org/0000-0001-6219-3897
Journal name Mini-reviews in medicinal chemistry
Volume number 16
Issue number Mini-reviews issue
Start page 1
End page 40
Total pages 40
Publisher Bentham Science Publishers
Place of publication Beijing, China
Publication date 2016
ISSN 1389-5575
1875-5607
Keyword(s) mesoporous silica nanoparticles
targeted drug delivery
computational design
controlled release
targeted drug delivery.
Summary Mesoporous silica nanoparticles (MSNs) are exceptionally promising drug carriers for controlled drug delivery systems because their morphology, pore structure, pore volume and pore size can be well tailored to obtain certain drug release profiles. Moreover, they possess the ability to specifically transport and deliver anti-cancer drugs when targeting molecules are properly grafted onto their surface. MSNs based drug delivery systems have the potential to revolutionize cancer therapy. This review provides a comprehensive overview of the fabrication, modification of MSNs and their applications in tumour-targeted delivery. In addition, the characterization and analysis of MSNs with computer aided strategies were described. The existing issues and future prospective concerning the applications of MSNs as drug carriers for controlled drug delivery systems were discussed.
Notes In Press
Language eng
DOI 10.2174/1389557516666160505114814
Field of Research 091201 Ceramics
110103 Medical Biochemistry: Inorganic Elements and Compounds
111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
0304 Medicinal And Biomolecular Chemistry
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083433

Document type: Journal Article
Collections: School of Medicine
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