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Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells

Li, Pu-Wang, Wang, Guang, Yang, Zi-Ming, Duan, Wei, Peng, Zheng, Kong, Ling-Xue and Wang, Qing-Huang 2016, Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells, Drug delivery, vol. 23, no. 1, pp. 30-35, doi: 10.3109/10717544.2014.900590.

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Title Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells
Author(s) Li, Pu-Wang
Wang, Guang
Yang, Zi-Ming
Duan, Wei
Peng, Zheng
Kong, Ling-XueORCID iD for Kong, Ling-Xue orcid.org/0000-0001-6219-3897
Wang, Qing-Huang
Journal name Drug delivery
Volume number 23
Issue number 1
Start page 30
End page 35
Total pages 6
Publisher Taylor & Francis
Place of publication Abingdon, Eng.
Publication date 2016
ISSN 1071-7544
1521-0464
Keyword(s) chitosan
cytotoxicity
drug delivery system
nanoparticles
vanillin
Summary Chitosan as a natural polysaccharide derived from chitin of arthropods like shrimp and crab, attracts much interest due to its inherent properties, especially for application in biomedical materials. Presently, biodegradable and biocompatible chitosan nanoparticles are attractive for drug delivery. However, some physicochemical characteristics of chitosan nanoparticles still need to be further improved in practice. In this work, chitosan nanoparticles were produced by crosslinking chitosan with 3-methoxy-4-hydroxybenzaldehyde (vanillin) through a Schiff reaction. Chitosan nanoparticles were 200-250 nm in diameter with smooth surface and were negatively charged with a zeta potential of - 17.4 mV in neutral solution. Efficient drug loading and drug encapsulation were achieved using 5-fluorouracil as a model of hydrophilic drug. Drug release from the nanoparticles was constant and controllable. The in vitro cytotoxicity against HT-29 cells and cellular uptake of the chitosan nanoparticles were evaluated by methyl thiazolyl tetrazolium method, confocal laser scanning microscope and flow cytometer, respectively. The results indicate that the chitosan nanoparticles crosslinked with vanillin are a promising vehicle for the delivery of anticancer drugs.
Language eng
DOI 10.3109/10717544.2014.900590
Field of Research 090301 Biomaterials
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Informa UK
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083436

Document type: Journal Article
Collection: Institute for Frontier Materials
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