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Choice of controls for a case-control study in Bangladesh: hospital controls versus community controls

Rahman, Muhammad Aziz, Spurrier, Nicola, Mahmood, Mohammad Afzal, Rahman, Mahmudur, Choudhury, Sohel Reza and Leeder, Stephen 2012, Choice of controls for a case-control study in Bangladesh: hospital controls versus community controls, Asian journal of epidemiology, vol. 5, no. 3, pp. 75-86, doi: 10.3923/aje.2012.75.86.

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Title Choice of controls for a case-control study in Bangladesh: hospital controls versus community controls
Author(s) Rahman, Muhammad AzizORCID iD for Rahman, Muhammad Aziz orcid.org/0000-0003-1665-7966
Spurrier, Nicola
Mahmood, Mohammad Afzal
Rahman, Mahmudur
Choudhury, Sohel Reza
Leeder, Stephen
Journal name Asian journal of epidemiology
Volume number 5
Issue number 3
Start page 75
End page 86
Total pages 12
Publisher Asian Network for Scientific Information
Place of publication Faisalabad, Pakistan
Publication date 2012
ISSN 1992-1462
2077-205X
Summary The study aimed to determine whether hospital controls could be used in case-control studies with minimal bias, where resource constraints limit recruitment of community controls. Hospital controls and community controls were compared for socio-demographic and risk factor variables in a study of Smokeless Tobacco (SLT) use and Coronary Heart Disease (CHD) in Bangladesh in 2010. Incident cases of CHD and hospital controls were selected from cardiac hospitals. Community controls were selected from neighbourhoods of CHD cases. We enrolled 302 cases, 302 hospital controls, and 1208 community controls. Distribution of age, gender, marital status, occupation, and socio-economic status was similar between hospital controls and community controls. Compared to community controls, hospital controls were more educated, had higher rates of hypertension and reported more family history of heart diseases. But they reported relatively less physical activity. Current use of SLT was higher amongst community controls compared to hospital controls, but was not significant (adjusted OR 0.81, 95% CI 0.58-1.12). Current use of SLT was not associated with an increased risk of CHD when community controls were used (adjusted OR 0.87, 95% CI 0.63 to 1.19, p>0.05), nor when hospital controls were used (adjusted OR 1.00, 95% CI 0.63 to 1.60, p>0.05). There were significant differences between two control groups but only on confounding variables which could be measured and adjusted for during multivariate analyses. For comparable future studies in resource-scarce settings, it is possible to enrol hospital controls with careful planning which are similar to potential community controls, whilst minimising selection bias.
Language eng
DOI 10.3923/aje.2012.75.86
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Socio Economic Objective 920199 Clinical Health (Organs
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Asian Network for Scientific Information
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083586

Document type: Journal Article
Collection: School of Medicine
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