Age-specific trends from 2000-2011 in all-cause and cause-specific mortality in type 1 and type 2 diabetes: a cohort study of more than one million people

Harding, Jessica L., Shaw, Jonathan E., Peeters, Anna, Davidson, Susan and Magliano, Dianna J. 2016, Age-specific trends from 2000-2011 in all-cause and cause-specific mortality in type 1 and type 2 diabetes: a cohort study of more than one million people, Diabetes care, vol. 39, no. 6, pp. 1018-1026, doi: 10.2337/dc15-2308.

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Title Age-specific trends from 2000-2011 in all-cause and cause-specific mortality in type 1 and type 2 diabetes: a cohort study of more than one million people
Author(s) Harding, Jessica L.
Shaw, Jonathan E.
Peeters, AnnaORCID iD for Peeters, Anna orcid.org/0000-0003-4340-9132
Davidson, Susan
Magliano, Dianna J.
Journal name Diabetes care
Volume number 39
Issue number 6
Start page 1018
End page 1026
Total pages 9
Publisher American Diabetes Association
Place of publication Alexandria, Va.
Publication date 2016-06
ISSN 0149-5992
1935-5548
Keyword(s) diabetes
health
age-group
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
CORONARY-HEART-DISEASE
CARDIOVASCULAR MORTALITY
EXCESS MORTALITY
GLYCEMIC CONTROL
NATIONAL-HEALTH
RISK-FACTORS
TIME TRENDS
7 COUNTRIES
FOLLOW-UP
MELLITUS
Summary OBJECTIVE: To analyze changes by age-group in all-cause and cause-specific mortality rates from 2000-2011 in people with diabetes. RESEARCH DESIGN AND METHODS: A total of 1,189,079 (7.3% with type 1 diabetes) Australians with diabetes registered on the National Diabetes Service Scheme between 2000 and 2011 were linked to the National Death Index. Mortality rates in the total population were age standardized to the 2001 Australian population. Mortality rates were calculated for the following age-groups: 0 to <40 years, ≥ 40 to <60 years, and ≥60 to ≤85 years. Annual mortality rates were fitted using a Poisson regression model including calendar year as a covariate and age and sex where appropriate, with Ptrend reported. RESULTS: For type 1 diabetes, all-cause, cardiovascular disease (CVD), and diabetes age-standardized mortality rates (ASMRs) decreased each year by 0.61, 0.35, and 0.14 per 1,000 person-years (PY), respectively, between 2000 and 2011, Ptrend < 0.05, while cancer mortality remained unchanged. By age, significant decreases in all-cause, CVD, and diabetes mortality rates were observed in all age-groups, excluding diabetes mortality in age-group 0-40 years. For type 2 diabetes, all-cause, CVD, and diabetes ASMRs decreased per year by 0.18, 0.15, and 0.03 per 1,000 PY, respectively, Ptrend < 0.001, while cancer remained unchanged. By age, these decreases were observed in all age-groups, excluding 0-40 years, where significant increases in all-cause and cancer mortality were noted and no change was seen for CVD and diabetes mortality. CONCLUSIONS: All-cause, CVD, and diabetes ASMRs in type 1 and type 2 diabetes decreased between 2000 and 2011, while cancer ASMRs remained unchanged. However, younger populations are not benefiting from the same improvements as older populations. In addition, the absence of a decline in cancer mortality warrants urgent attention.
Language eng
DOI 10.2337/dc15-2308
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Diabetes Association.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083634

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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