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Relationship between erythrocyte fatty acid composition and psychopathology in the Vienna omega-3 study

Kim, Sung-Wan, Jhon, Min, Kim, Jae-Min, Smesny, Stefan, Rice, Simon, Berk, Michael, Klier, Claudia M., McGorry, Patrick D., Schäfer, Miriam R. and Amminger, G. Paul 2016, Relationship between erythrocyte fatty acid composition and psychopathology in the Vienna omega-3 study, PLoS one, vol. 11, no. 3, Article number : e0151417, pp. 1-12, doi: 10.1371/journal.pone.0151417.

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Title Relationship between erythrocyte fatty acid composition and psychopathology in the Vienna omega-3 study
Author(s) Kim, Sung-Wan
Jhon, Min
Kim, Jae-Min
Smesny, Stefan
Rice, Simon
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Klier, Claudia M.
McGorry, Patrick D.
Schäfer, Miriam R.
Amminger, G. Paul
Journal name PLoS one
Volume number 11
Issue number 3
Season Article number : e0151417
Start page 1
End page 12
Total pages 12
Publisher PLoS
Place of publication San Francisco, Calif.
Publication date 2016
ISSN 1932-6203
Keyword(s) adolescent
adult
Austria
erythrocyte membrane
erythrocytes
fatty acids
fatty acids, omega-3
female
humans
male
psychopathology
psychotic disorders
young adult
Summary This study investigated the relationship between erythrocyte membrane fatty acid (FA) levels and the severity of symptoms of individuals at ultra-high risk (UHR) for psychosis. Subjects of the present study consisted of 80 neuroleptic-naïve UHR patients. Partial correlation coefficients were calculated between baseline erythrocyte membrane FA levels, measured by gas chromatography, and scores on the Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning Scale, and Montgomery-Asberg Depression Rating Scale (MADRS) after controlling for age, sex, smoking and cannabis use. Subjects were divided into three groups according to the predominance of positive or negative symptoms based on PANSS subscale scores; membrane FA levels in the three groups were then compared. More severe negative symptoms measured by PANSS were negatively correlated with two saturated FAs (myristic and margaric acids), one ω-9 monounsaturated FA (MUFA; nervonic acid), and one ω-3 polyunsaturated FA (PUFA; docosapentaenoic acid), and were positively correlated with two ω-9 MUFAs (eicosenoic and erucic acids) and two ω-6 PUFAs (γ-linolenic and docosadienoic acids). More severe positive symptoms measured by PANSS were correlated only with nervonic acid. No associations were observed between FAs and MADRS scores. In subjects with predominant negative symptoms, the sum of the ω-9 MUFAs and the ω-6:ω-3 FA ratio were both significantly higher than in those with predominant positive symptoms, whereas the sum of ω-3 PUFAs was significantly lower. In conclusion, abnormalities in FA metabolism may contribute to the neurobiology of psychopathology in UHR individuals. In particular, membrane FA alterations may play a role in negative symptoms, which are primary psychopathological manifestations of schizophrenia-related disability.
Language eng
DOI 10.1371/journal.pone.0151417
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083782

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Created: Mon, 10 Oct 2016, 10:46:29 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.