MicroRNAs in a hypertrophic heart: from foetal life to adulthood

Sadiq, Shahzad, Crowley, Tamsyn M., Charchar, Fadi J., Sanigorski, Andrew and Lewandowski, Paul A. 2016, MicroRNAs in a hypertrophic heart: from foetal life to adulthood, Biological reviews : Cambridge philosophical society, In Press, pp. 1-18, doi: 10.1111/brv.12283.

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Title MicroRNAs in a hypertrophic heart: from foetal life to adulthood
Author(s) Sadiq, Shahzad
Crowley, Tamsyn M.ORCID iD for Crowley, Tamsyn M. orcid.org/0000-0002-3698-8917
Charchar, Fadi J.
Sanigorski, AndrewORCID iD for Sanigorski, Andrew orcid.org/0000-0002-2858-4621
Lewandowski, Paul A.
Journal name Biological reviews : Cambridge philosophical society
Season In Press
Start page 1
End page 18
Total pages 18
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 2016-05
ISSN 1469-185X
Keyword(s) anti-sense therapy
apoptosis
biomarkers
cardiac hypertrophy
cardiogenesis
hypertrophic heart rat
microRNAs
Summary The heart is the first organ to form and undergoes adaptive remodelling with age. Ventricular hypertrophy is one such adaptation, which allows the heart to cope with an increase in cardiac demand. This adaptation is necessary as part of natural growth from foetal life to adulthood. It may also occur in response to resistance in blood flow due to various insults on the heart and vessels that accumulate with age. The heart can only compensate to this increase in workload to a certain extent without losing its functional architecture, ultimately resulting in heart failure. Many genes have been implicated in cardiac hypertrophy, however none have been shown conclusively to be responsible for pathological cardiac hypertrophy. MicroRNAs offer an alternative mechanism for cellular regulation by altering gene expression. Since 1993 when the function of a non-coding DNA sequence was first discovered in the model organism Caenorhabditis elegans, many microRNAs have been implicated in having a central role in numerous physiological and pathological cellular processes. The level of control these antisense oligonucleotides offer can often be exploited to manipulate the expression of target genes. Moreover, altered levels of microRNAs can serve as diagnostic biomarkers, with the prospect of diagnosing a disease process as early as during foetal life. Therefore, it is vital to ascertain and investigate the function of microRNAs that are involved in heart development and subsequent ventricular remodelling. Here we present an overview of the complicated network of microRNAs and their target genes that have previously been implicated in cardiogenesis and hypertrophy. It is interesting to note that microRNAs in both of these growth processes can be of possible remedial value to counter a similar disease pathophysiology.
Language eng
DOI 10.1111/brv.12283
Field of Research 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified
Socio Economic Objective 920101 Blood Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30083960

Document type: Journal Article
Collection: School of Medicine
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