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Is low vitamin D status a risk factor for food allergy? Current evidence and future directions

Molloy, John, Ponsonby, Anne-Louise, Allen, Katrina J., Tang, Mimi L. K., Collier, Fiona M., Ward, Alister C., Koplin, Jennifer and Vuillermin, Peter 2015, Is low vitamin D status a risk factor for food allergy? Current evidence and future directions, Mini-reviews in medicinal chemistry, vol. 15, no. 11, pp. 944-952, doi: 10.2174/1389557515666150519111328#sthash.4dcj5Wiq.dpuf.

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Title Is low vitamin D status a risk factor for food allergy? Current evidence and future directions
Author(s) Molloy, John
Ponsonby, Anne-Louise
Allen, Katrina J.
Tang, Mimi L. K.
Collier, Fiona M.
Ward, Alister C.ORCID iD for Ward, Alister C.
Koplin, Jennifer
Vuillermin, Peter
Journal name Mini-reviews in medicinal chemistry
Volume number 15
Issue number 11
Start page 944
End page 952
Total pages 9
Publisher Bentham Science Publishers
Place of publication Hilversum, The Netherlands
Publication date 2015
ISSN 1389-5575
Keyword(s) Fetal Blood
Food Hypersensitivity
Genetic Predisposition to Disease
Risk Factors
Vitamin D
Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
Food allergy
genetic factors
gut microbiome
vitamin D status
Summary Studies from several countries have reported an association between latitudes further from the equator and proxy markers of food allergy prevalence. As latitudes further from the equator are associated with lower sun exposure and vitamin D status (VDS), it has been proposed that low VDS may be a risk factor for food allergy. A range of basic science evidence supports the biological plausibility of this hypothesis; and recent work has identified a cross sectional association between low VDS and challenge proven food allergy in infants. Overall, however, the evidence regarding the relationship between VDS and food allergy remains controversial and the limited longitudinal data are discouraging. In this review we consider the evidence for and against low VDS as a risk factor for food allergy and discuss the possibility that other factors (including genetic variables) may contribute to the inconsistent nature of the available observational evidence. We then discuss whether genetic and/or environmental factors may modify the potential influence of VDS on food allergy risk. Finally, we argue that given the rising burden of food allergy, the balance of available evidence regarding the potential relevance of VDS to this phenomenon, and the inherent limitations of the existing observational data, there is a compelling case for conducting randomised clinical trials of vitamin D supplementation for the prevention of food allergy during early life.
Language eng
DOI 10.2174/1389557515666150519111328#sthash.4dcj5Wiq.dpuf
Field of Research 110701 Allergy
0304 Medicinal And Biomolecular Chemistry
1115 Pharmacology And Pharmaceutical Sciences
110701 Allergy
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bentham Science Publishers
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Document type: Journal Article
Collection: School of Medicine
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