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Quality of life in children with advanced cancer: a report from the PediQUEST study

Rosenberg, Abby R., Orellana, Liliana, Ullrich, Christina, Kang, Tammy, Geyer, J. Russell, Feudtner, Chris, Dussel, Veronica and Wolfe, Joanne 2016, Quality of life in children with advanced cancer: a report from the PediQUEST study, Journal of pain and symptom management, vol. 52, no. 2, pp. 243-253, doi: 10.1016/j.jpainsymman.2016.04.002.

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Title Quality of life in children with advanced cancer: a report from the PediQUEST study
Author(s) Rosenberg, Abby R.
Orellana, LilianaORCID iD for Orellana, Liliana orcid.org/0000-0003-3736-4337
Ullrich, Christina
Kang, Tammy
Geyer, J. Russell
Feudtner, Chris
Dussel, Veronica
Wolfe, Joanne
Journal name Journal of pain and symptom management
Volume number 52
Issue number 2
Start page 243
End page 253
Total pages 11
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-08
ISSN 1873-6513
Keyword(s) Quality of life
end of life
palliative care
patient-reported outcomes
pediatric cancer
symptom distress
Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Medicine, General & Internal
Clinical Neurology
General & Internal Medicine
Neurosciences & Neurology
Summary CONTEXT: Modifiable factors of health-related quality of life (HRQOL) are poorly described among children with advanced cancer. Symptom distress may be an important factor for intervention. OBJECTIVES: We aimed to describe patient-reported HRQOL and its relationship to symptom distress. METHODS: Prospective, longitudinal data from the multicenter Pediatric Quality of Life and Symptoms Technology study included primarily patient-reported symptom distress and HRQOL, measured at most weekly with the Memorial Symptoms Assessment Scale and Pediatric Quality of Life inventory, respectively. Associations were evaluated using linear mixed-effects models adjusting for sex, age, cancer type, intervention arm, treatment intensity, and time since disease progression. RESULTS: Of 104 enrolled patients, 49% were female, 89% were white, and median age was 12.6 years. Nine hundred and twenty surveys were completed over nine months of follow-up (84% by patients). The median total Pediatric Quality of Life score was 74 (interquartile range 63-87) and was "poor/fair" (e.g., <70) 38% of the time. "Poor/fair" categories were highest in physical (53%) and school (48%) compared to emotional (24%) and social (16%) subscores. Thirteen of 24 symptoms were independently associated with reductions in overall or domain-specific HRQOL. Patients commonly reported distress from two or more symptoms, corresponding to larger HRQOL score reductions. Neither cancer type, time since progression, treatment intensity, sex, nor age was associated with HRQOL scores in multivariable models. Among 25 children completing surveys during the last 12 weeks of life, 11 distressing symptoms were associated with reductions in HRQOL. CONCLUSION: Symptom distress is strongly associated with HRQOL. Future research should determine whether alleviating distressing symptoms improves HRQOL in children with advanced cancer.
Language eng
DOI 10.1016/j.jpainsymman.2016.04.002
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084097

Document type: Journal Article
Collection: Faculty of Health
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Created: Mon, 27 Jun 2016, 12:13:57 EST

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