A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: a meta-analysis

Dawson, Samantha Loren, Bowe, Steven John and Crowe, Timothy Charles 2016, A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: a meta-analysis, Nutrition research, vol. 36, no. 6, pp. 499-508, doi: 10.1016/j.nutres.2016.03.010.

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Title A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: a meta-analysis
Author(s) Dawson, Samantha Loren
Bowe, Steven JohnORCID iD for Bowe, Steven John orcid.org/0000-0003-3813-842X
Crowe, Timothy Charles
Journal name Nutrition research
Volume number 36
Issue number 6
Start page 499
End page 508
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-06
ISSN 1879-0739
Keyword(s) B-group Vitamins
Folic acid
Homocysteine
Meta-analysis
Omega-3 PUFAs
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
STAGE RENAL-DISEASE
POLYUNSATURATED FATTY-ACIDS
PERIPHERAL VASCULAR-DISEASE
C-REACTIVE PROTEIN
PLASMA HOMOCYSTEINE
CARDIOVASCULAR-DISEASE
OLEIC-ACID
FISH-OIL
CONTROLLED-TRIAL
GENE-EXPRESSION
Summary The aim of the study was to assess whether omega-3 polyunsaturated fatty acid supplementation alone or in combination with folic acid and B-group vitamins is effective in lowering homocysteine. The Medline Ovid, Embase and Cochrane databases were searched for randomized-controlled trial studies that intervened with omega-3 supplementation (with or without folic acid) and measured changes in homocysteine concentration. Studies were pooled using a random effects model for meta-analysis. Three different models were analyzed: all trials combined, omega-3 polyunsaturated fatty acid trials, and omega-3 polyunsaturated fatty acids with folic acid and B-group vitamin trials. Nineteen studies were included, consisting of 3267 participants completing 21 trials. Studies were heterogeneous; varying by dose, duration and participant health conditions. Across all trials, omega-3 supplementation was effective in lowering homocysteine by an average of 1.18μmol/L (95%CI: (-1.89, -0.48), P=.001). The average homocysteine-lowering effect was greater when omega-3 supplementation was combined with folic acid and B-group vitamins (-1.37μmol/L, 95%CI: (-2.38, -0.36), P<.01) compared to omega-3 supplementation alone (-1.09μmol/L 95%CI: (-2.04, -0.13), P=.03). Omega-3 polyunsaturated fatty acid supplementation was associated with a modest reduction in homocysteine. For the purposes of reducing homocysteine, a combination of omega-3s (0.2-6g/day), folic acid (150 - 2500μg/day) and vitamins B6 and B12 may be more effective than omega-3 supplementation alone.
Language eng
DOI 10.1016/j.nutres.2016.03.010
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
1111 Nutrition And Dietetics
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084277

Document type: Journal Article
Collection: Faculty of Health
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