Evaluations of treatment efficacy of depression from perspective of both patients' symptoms and general sense of mental health and wellbeing: a large scale, multi-centered, longitudinal study in China

Zeng, Qingzhi, Wang, Wei Chun, Fang, Yiru, Mellor, David, Mc Cabe, Marita, Byrne, Linda, Zuo, Sai and Xu, Yifeng 2016, Evaluations of treatment efficacy of depression from perspective of both patients' symptoms and general sense of mental health and wellbeing: a large scale, multi-centered, longitudinal study in China, Psychiatry research, vol. 241, pp. 55-60, doi: 10.1016/j.psychres.2016.04.111.

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Title Evaluations of treatment efficacy of depression from perspective of both patients' symptoms and general sense of mental health and wellbeing: a large scale, multi-centered, longitudinal study in China
Author(s) Zeng, Qingzhi
Wang, Wei ChunORCID iD for Wang, Wei Chun orcid.org/0000-0003-4287-1704
Fang, Yiru
Mellor, DavidORCID iD for Mellor, David orcid.org/0000-0001-5007-5906
Mc Cabe, Marita
Byrne, LindaORCID iD for Byrne, Linda orcid.org/0000-0001-9055-0046
Zuo, Sai
Xu, Yifeng
Journal name Psychiatry research
Volume number 241
Start page 55
End page 60
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-07-30
ISSN 0165-1781
1872-7123
Keyword(s) symptom
mental health
wellbeing
hamilton rating scale for depression (HRSD-17)
observational design, remission evaluation and mood inventory tool (REMIT)
Science & Technology
Life Sciences & Biomedicine
Psychiatry
RATING-SCALE
ANTIDEPRESSANT
REMISSION
METAANALYSIS
OUTPATIENTS
THEMSELVES
SEVERITY
VALIDITY
DISORDER
Summary Relying on the absence, presence of level of symptomatology may not provide an adequate indication of the effects of treatment for depression, nor sufficient information for the development of treatment plans that meet patients' needs. Using a prospective, multi-centered, and observational design, the present study surveyed a large sample of outpatients with depression in China (n=9855). The 17-item Hamilton Rating Scale for Depression (HRSD-17) and the Remission Evaluation and Mood Inventory Tool (REMIT) were administered at baseline, two weeks later and 4 weeks, to assess patients' self-reported symptoms and general sense of mental health and wellbeing. Of 9855 outpatients, 91.3% were diagnosed as experiencing moderate to severe depression. The patients reported significant improvement over time on both depressive symptoms and general sense after 4-week treatment. The effect sizes of change in general sense were lower than those in symptoms at both two week and four week follow-up. Treatment effects on both general sense and depressive symptomatology were associated with demographic and clinical factors. The findings indicate that a focus on both general sense of mental health and wellbeing in addition to depressive symptomatology will provide clinicians, researchers and patients themselves with a broader perspective of the status of patients.
Language eng
DOI 10.1016/j.psychres.2016.04.111
Field of Research 170199 Psychology not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier Ireland Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084294

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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