Selective sensing of pyrophosphate in physiological media using zinc( ii )dipicolylamino-functionalised peptides

Zwicker, Vincent E., Long, Benjamin M. and Jolliffe, Katrina A. 2015, Selective sensing of pyrophosphate in physiological media using zinc( ii )dipicolylamino-functionalised peptides, Organic and biomolecular chemistry, vol. 13, no. 28, pp. 7822-7829, doi: 10.1039/C5OB00956A.

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Title Selective sensing of pyrophosphate in physiological media using zinc( ii )dipicolylamino-functionalised peptides
Author(s) Zwicker, Vincent E.
Long, Benjamin M.ORCID iD for Long, Benjamin M.
Jolliffe, Katrina A.
Journal name Organic and biomolecular chemistry
Volume number 13
Issue number 28
Start page 7822
End page 7829
Total pages 8
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2015
ISSN 1477-0539
Keyword(s) pyrophosphate
anion receptors
Krebs buffer
Summary A series of linear peptide based anion receptors, in which the distance between the bis[zinc(II)dipicolylamine] binding sites and the peptide backbone was varied systematically, was prepared and their anion binding ability was investigated using indicator displacement assays. Shortening the distance between the binding site and the peptide backbone was found to enhance both the receptor affinity and selectivity for pyrophosphate over other organic polyphosphate anions in Krebs buffer with the maximum selectivity and affinity observed with a spacer length of two methylene units. The suitability of these receptors for the determination of pyrophosphate concentrations in Krebs buffer and in artificial urine was examined.
Language eng
DOI 10.1039/C5OB00956A
Field of Research 0304 Medicinal And Biomolecular Chemistry
0305 Organic Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Royal Society of Chemistry
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