You are not logged in.

Selective sensing of pyrophosphate in physiological media using zinc( ii )dipicolylamino-functionalised peptides

Zwicker, Vincent E., Long, Benjamin M. and Jolliffe, Katrina A. 2015, Selective sensing of pyrophosphate in physiological media using zinc( ii )dipicolylamino-functionalised peptides, Organic and biomolecular chemistry, vol. 13, no. 28, pp. 7822-7829, doi: 10.1039/C5OB00956A.

Attached Files
Name Description MIMEType Size Downloads

Title Selective sensing of pyrophosphate in physiological media using zinc( ii )dipicolylamino-functionalised peptides
Author(s) Zwicker, Vincent E.
Long, Benjamin M.
Jolliffe, Katrina A.
Journal name Organic and biomolecular chemistry
Volume number 13
Issue number 28
Start page 7822
End page 7829
Total pages 8
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2015
ISSN 1477-0539
1477-0539
Keyword(s) pyrophosphate
anion receptors
Krebs buffer
Summary A series of linear peptide based anion receptors, in which the distance between the bis[zinc(II)dipicolylamine] binding sites and the peptide backbone was varied systematically, was prepared and their anion binding ability was investigated using indicator displacement assays. Shortening the distance between the binding site and the peptide backbone was found to enhance both the receptor affinity and selectivity for pyrophosphate over other organic polyphosphate anions in Krebs buffer with the maximum selectivity and affinity observed with a spacer length of two methylene units. The suitability of these receptors for the determination of pyrophosphate concentrations in Krebs buffer and in artificial urine was examined.
Language eng
DOI 10.1039/C5OB00956A
Field of Research 0304 Medicinal And Biomolecular Chemistry
0305 Organic Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084313

Document type: Journal Article
Collection: School of Life and Environmental Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in TR Web of Science
Scopus Citation Count Cited 8 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 51 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Mon, 18 Jul 2016, 12:53:27 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.