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A potential role for N-acetylcysteine in the management of methamphetamine dependence

McKetin, Rebecca, Dean, Olivia M., Baker, Amanda L., Carter, Greg, Turner, Alyna, Kelly, Peter J. and Berk, Michael 2016, A potential role for N-acetylcysteine in the management of methamphetamine dependence, Drug and alcohol review, Early view, pp. 1-7, doi: 10.1111/dar.12414.

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Title A potential role for N-acetylcysteine in the management of methamphetamine dependence
Author(s) McKetin, Rebecca
Dean, Olivia M.ORCID iD for Dean, Olivia M.
Baker, Amanda L.
Carter, Greg
Turner, AlynaORCID iD for Turner, Alyna
Kelly, Peter J.
Berk, MichaelORCID iD for Berk, Michael
Journal name Drug and alcohol review
Season Early view
Start page 1
End page 7
Total pages 7
Publisher Wiley
Place of publication London, Eng.
Publication date 2016-05-30
ISSN 1465-3362
Keyword(s) N-acetylcysteine
drug therapy
Summary Methamphetamine dependence is a growing problem in Australia and globally. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. N-acetylcysteine is one potential pharmacotherapy option. It has received growing attention as a therapy for managing addictions because of its capacity to restore homeostasis to brain glutamate systems disrupted in addiction and thereby reduce craving and the risk of relapse. N-acetylcysteine also has antioxidant properties that protect against methamphetamine-induced toxicity and it may therefore assist in the management of the neuropsychiatric and neurocognitive effects of methamphetamine. This commentary overviews the actions of N-acetylcysteine and evidence for its efficacy in treating addiction with a particular focus on its potential utility for methamphetamine dependence. We conclude that the preliminary evidence indicates a need for full-scale trials to definitively establish whether N-acetylcysteine has a therapeutic benefit and the nature of this benefit, for managing methamphetamine dependence.
Language eng
DOI 10.1111/dar.12414
Field of Research 110319 Psychiatry (incl Psychotherapy)
111714 Mental Health
11 Medical And Health Sciences
16 Studies In Human Society
17 Psychology And Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Wiley
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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Created: Tue, 28 Jun 2016, 11:38:54 EST

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