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Epigenetic regulation of skeletal muscle metabolism

Howlett, Kirsten F. and McGee, Sean L. 2016, Epigenetic regulation of skeletal muscle metabolism, Clinical science, vol. 130, no. 13, pp. 1051-1063, doi: 10.1042/CS20160115.

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Title Epigenetic regulation of skeletal muscle metabolism
Author(s) Howlett, Kirsten F.ORCID iD for Howlett, Kirsten F. orcid.org/0000-0002-8571-4867
McGee, Sean L.
Journal name Clinical science
Volume number 130
Issue number 13
Start page 1051
End page 1063
Total pages 13
Publisher Portland Press
Place of publication London, Eng.
Publication date 2016-05-23
ISSN 1470-8736
Keyword(s) acetylation
epigenetics
gene expression
methylation
muscle metabolism
Summary Normal skeletal muscle metabolism is essential for whole body metabolic homoeostasis and disruptions in muscle metabolism are associated with a number of chronic diseases. Transcriptional control of metabolic enzyme expression is a major regulatory mechanism for muscle metabolic processes. Substantial evidence is emerging that highlights the importance of epigenetic mechanisms in this process. This review will examine the importance of epigenetics in the regulation of muscle metabolism, with a particular emphasis on DNA methylation and histone acetylation as epigenetic control points. The emerging cross-talk between metabolism and epigenetics in the context of health and disease will also be examined. The concept of inheritance of skeletal muscle metabolic phenotypes will be discussed, in addition to emerging epigenetic therapies that could be used to alter muscle metabolism in chronic disease states.
Language eng
DOI 10.1042/CS20160115
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084716

Document type: Journal Article
Collection: School of Medicine
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