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An investigation of effects of modification processes on physical properties and mechanism of drug release for sustaining drug release from modified rice

Ngo, Vuong D., Luu, Thinh D., Van Vo, Toi, Tran, Van-Thanh, Duan, Wei, Tran, Phuong Ha-Lien and Tran, Thao T-D. 2016, An investigation of effects of modification processes on physical properties and mechanism of drug release for sustaining drug release from modified rice, Materials science and engineering C, vol. 67, pp. 1-7, doi: 10.1016/j.msec.2016.04.098.

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Title An investigation of effects of modification processes on physical properties and mechanism of drug release for sustaining drug release from modified rice
Author(s) Ngo, Vuong D.
Luu, Thinh D.
Van Vo, Toi
Tran, Van-Thanh
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Tran, Phuong Ha-LienORCID iD for Tran, Phuong Ha-Lien orcid.org/0000-0001-8463-7516
Tran, Thao T-D.
Journal name Materials science and engineering C
Volume number 67
Start page 1
End page 7
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-10-01
ISSN 1873-0191
Keyword(s) Flow property
Incubation
Modified rice
Morphology
Sustained release
Summary The aim of this study was to investigate the effect of modification processes on physical properties and explain the mechanism of sustained drug release from modified rice (MR). Various types of Vietnamese rice were introduced in the study as the matrices of sustained release dosage form. Rice was thermally modified in water for a determined temperature at different times with a simple process. Then tablets containing MR and isradipine, the model drug, were prepared to investigate the capability of sustained drug release. Scanning electron microscopy (SEM) was used to determine different morphologies between MR formulations. Flow property of MR was analyzed by Hausner ratio and Carr's indices. The dissolution rate and swelling/erosion behaviors of tablets were evaluated at pH 1.2 and pH6.8 at 37±0.5°C. The matrix tablet containing MR showed a sustained release as compared to the control. The SEM analyses and swelling/erosion studies indicated that the morphology as well as swelling/erosion rate of MR were modulated by modification time, drying method and incubation. It was found that the modification process was crucial because it could highly affect the granule morphologies and hence, leading to the change of flowability and swelling/erosion capacity for sustained release of drug.
Language eng
DOI 10.1016/j.msec.2016.04.098
Field of Research 0903 Biomedical Engineering
119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084721

Document type: Journal Article
Collection: School of Medicine
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