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Design of fucoidan functionalized - iron oxide nanoparticles for biomedical applications

Tran, Khanh Nghia, Ha-Lien Tran, Phuong, Vo, Toi Van and Tran, Truong-Dinh Thao 2016, Design of fucoidan functionalized - iron oxide nanoparticles for biomedical applications, Current drug delivery, vol. 13, no. 5, pp. 774-783, doi: 10.2174/1567201812666151020100921.

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Title Design of fucoidan functionalized - iron oxide nanoparticles for biomedical applications
Author(s) Tran, Khanh Nghia
Ha-Lien Tran, Phuong
Vo, Toi Van
Tran, Truong-Dinh Thao
Journal name Current drug delivery
Volume number 13
Issue number 5
Start page 774
End page 783
Total pages 10
Publisher Bentham Science
Place of publication Beijing, China
Publication date 2016
ISSN 1567-2018
Keyword(s) Fucoidan
Iron oxide nanoparticles
Paclitaxel
Curcumin
Ultrasonication
Summary This research aims to develop an iron oxide nanoparticle drug delivery system utilizing a recent material discovered from ocean, fucoidan. The material has drawn much interest due to many biomedical functions that have been proven for human health. One interesting point herein is that fucoidan is not only a sulfated polysaccharide, a polymer for stabilization of iron oxide nanoparticles, but plays a role of an anticancer agent also. Various approaches were investigated to optimize the high loading efficiency and explain the mechanism of nanoparticle formations. Fucoidan was functionalized on iron oxide nanoparticles by a direct coating or via amine groups. Also, a hydrophobic part of oleic acid was conjugated to the amine groups for a more favorable loading of poorly water-soluble anticancer drugs. This study proposed a novel system and an efficient method to functionalize fucoidan on iron oxide nanoparticle systems which will lead to a facilitation of a double strength treatment of cancer.
Language eng
DOI 10.2174/1567201812666151020100921
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bentham Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084722

Document type: Journal Article
Collection: School of Medicine
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