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Nano-precipitation : preparation and application in the field of pharmacy

Tran, Thao Truong-Dinh, Tran, Phuong Ha-Lien, Nguyen, Khanh Tu and Tran, Van-Thanh 2016, Nano-precipitation : preparation and application in the field of pharmacy, Current pharmaceutical design, vol. 22, no. 20, pp. 2997-3006, doi: 10.2174/1381612822666160408151702.

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Title Nano-precipitation : preparation and application in the field of pharmacy
Author(s) Tran, Thao Truong-Dinh
Tran, Phuong Ha-LienORCID iD for Tran, Phuong Ha-Lien orcid.org/0000-0001-8463-7516
Nguyen, Khanh Tu
Tran, Van-Thanh
Journal name Current pharmaceutical design
Volume number 22
Issue number 20
Start page 2997
End page 3006
Total pages 10
Publisher Bentham Science Publishers
Place of publication Beijing, China
Publication date 2016
ISSN 1381-6128
1873-4286
Keyword(s) nano-precipitation
anti-solvent
encapsulation efficiency
solid nano-protein
morphology
stability
Summary Over the last 30 years, nanoparticle-based medicine has received tremendous attention due to its advances with smart therapeutics and less toxicity. Few nanomedicine products have been approved for commercial use in the clinic (such as Doxil®, Ambraxane®…). Nanomedicine research is still at its early stage and the preparation of nanoparticles must be carefully considered. Systems involving further increased supersaturation, either via solvent evaporation, temperature reduction or anti-solvent mixture, were suggested to be capable of inducing nanoprecipitation (NPT). Since this technique is straight-forward, fast and easy to duplicate in practice, it is highly preferred and recommended. In this review, the process of NTP was described and discussed in detail. Factors that affect the encapsulation efficiency, the nanoparticle size, the morphology and the stability of nanoparticles prepared by NTP were described. This process is one of the most preferable processes for preparing solid nano-protein due to their elegant techniques that preserve the bioactivity of proteins. Although the production of nanoparticles by this process has not been applied in the pharmaceutical industry due to the organic solvent issue, the production equipment for large-scale has been marketed.
Language eng
DOI 10.2174/1381612822666160408151702
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084741

Document type: Journal Article
Collection: School of Medicine
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