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Investigation of Fucoidan–oleic acid conjugate for delivery of Curcumin and Paclitaxel

Phan, Uyen Thao, Nguyen, Khanh Tu, Vo, Toi Van, Duan, Wei, Tran, Phuong Ha-Lien and Tran, Thao Truong-Dinh 2016, Investigation of Fucoidan–oleic acid conjugate for delivery of Curcumin and Paclitaxel, Anti-cancer agents in medicinal chemistry, vol. 16, no. 10, pp. 1281-1287, doi: 10.2174/1567201810666131124140259.

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Title Investigation of Fucoidan–oleic acid conjugate for delivery of Curcumin and Paclitaxel
Author(s) Phan, Uyen Thao
Nguyen, Khanh Tu
Vo, Toi Van
Duan, Wei
Tran, Phuong Ha-Lien
Tran, Thao Truong-Dinh
Journal name Anti-cancer agents in medicinal chemistry
Volume number 16
Issue number 10
Start page 1281
End page 1287
Total pages 7
Publisher Bentham Science Publishers
Place of publication Beijing, China
Publication date 2016
ISSN 1871-5206
Keyword(s) Fucoidan
conjugate
micelle
cancer therapeutics
nanomedicine
Summary Nanoparticles for a specific delivery are likely to be designed for cancer therapeutic effectiveness and improvement. In this study, a fucoidan-oleic acid conjugate was prepared and investigated in terms of loading capacity for poorly water-soluble anti-cancer drugs to maximize effectiveness of the treatment. Fucoidan was used as a hydrophilic portion of an amphiphilic structure for improving cancer therapeutic effects. Paclitaxel and curcumin were chosen as other model drugs loaded in the conjugates. The results showed that self-assembled nanoparticles with different sizes and morphologies could be prepared with two different concentrations of oleic acid as hydrophobic portion. Moreover, loading efficiency and release patterns of these drugs were mainly dependent on the hydrophobic interaction between drugs and oleic acid. It was also revealed that fucoidan and curcumin were released higher at pH 4.5 than at the physiological condition (pH 7.4), thus, facilitating the delivery and maximizing effects of the anticancer agents on cancer cells. On the contrary, paclitaxel from fucoidan nanoparticles was released faster at pH 7.4. The exploration of fucoidan–oleic acid conjugate could be considered as promising nanomedicines for cancer therapeutics.
Language eng
DOI 10.2174/1567201810666131124140259
Field of Research 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
0304 Medicinal And Biomolecular Chemistry
1112 Oncology And Carcinogenesis
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084743

Document type: Journal Article
Collection: Molecular and Medical Research
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Created: Wed, 06 Jul 2016, 13:29:53 EST

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