Amoebiasis vaccine development: a snapshot on E. histolytica with emphasis on perspectives of Gal/GalNAc lectin

Singh, Ram Sarup, Walia, Amandeep Kaur, Kanwar, Jagat Rakesh and Kennedy, John F. 2016, Amoebiasis vaccine development: a snapshot on E. histolytica with emphasis on perspectives of Gal/GalNAc lectin, International journal of biological macromolecules, vol. 91, pp. 258-268, doi: 10.1016/j.ijbiomac.2016.05.043.

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Title Amoebiasis vaccine development: a snapshot on E. histolytica with emphasis on perspectives of Gal/GalNAc lectin
Author(s) Singh, Ram Sarup
Walia, Amandeep Kaur
Kanwar, Jagat RakeshORCID iD for Kanwar, Jagat Rakesh orcid.org/0000-0003-3728-9568
Kennedy, John F.
Journal name International journal of biological macromolecules
Volume number 91
Start page 258
End page 268
Total pages 11
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-10
ISSN 1879-0003
Keyword(s) lectin
pathogenesis
signalling
Summary Amoebiasis/amebiasis is a gastrointestinal infection caused by an enteric dwelling protozoan, Entamoeba histolytica. The disease is endemic in the developing world and is transmitted mainly via the faecal-oral route (e.g., in water or food) and may or may not be symptomatic. This disease of socio-economic importance worldwide involves parasite adherence and cytolysis of human cells followed by invasion that is mediated by galactose-binding (Gal/GalNAc) surface lectin. Disruption of the mucus layer leads to invasive intestinal and extraintestinal infection. Gal-lectin based vaccinations have conferred protection in various animal models against E. histolytica infections. Keeping in view the pivotal role of Gal/GalNAc lectin in amoebiasis vaccine development, its regulation, genomic view of the parasite involving gene conversion in lectin gene families, current knowledge about involvement of Gal/GalNAc lectin in adherence, pathogenicity, signalling, encystment, generating host immune response, and in turn protozoa escape strategies, and finally its role as effective vaccine candidate has been described. This review will help researchers to explore pathogenesis mechanism along with genomic studies and will also provide a framework for future amoebiasis vaccine development studies.
Language eng
DOI 10.1016/j.ijbiomac.2016.05.043
Field of Research 111799 Public Health and Health Services not elsewhere classified
0601 Biochemistry And Cell Biology
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084745

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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