ANXA2 enhances the progression of hepatocellular carcinoma via remodeling the cell motility associated structures

Shi, Hongyan, Xiao, Li, Duan, Wei, He, Huimin, Ma, Lele, Da, Miaomiao, Duan, Yan, Wang, Qian, Wu, Huayi, Song, Xigui and Hou, Yingchun 2016, ANXA2 enhances the progression of hepatocellular carcinoma via remodeling the cell motility associated structures, Micron, vol. 85, pp. 26-33, doi: 10.1016/j.micron.2016.03.008.

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Title ANXA2 enhances the progression of hepatocellular carcinoma via remodeling the cell motility associated structures
Author(s) Shi, Hongyan
Xiao, Li
Duan, WeiORCID iD for Duan, Wei
He, Huimin
Ma, Lele
Da, Miaomiao
Duan, Yan
Wang, Qian
Wu, Huayi
Song, Xigui
Hou, Yingchun
Journal name Micron
Volume number 85
Start page 26
End page 33
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-06
ISSN 1878-4291
Keyword(s) ANXA2
Cell behaviors
Cell structures
Gene expression
Hepatocellular carcinoma
Science & Technology
Summary Hepatocellular carcinoma (HCC) ranks as the fifth most common malignancy worldwide. The detailed mechanism of signal regulation for HCC progression is still not known, and the high motility of cancer cells is known as a core property for cancer progression maintenance. Annexin A2 (ANXA2), a calcium-dependent phospholipids binding protein is highly expressed in HCC. To study the roles the excessively expressed ANXA2 during the progression of HCC, we inhibited the ANXA2 expression in SMMC-7721 cells using RNAi, followed by the analysis of cell growth, apoptosis and cell motility. To explore the relationship between the cell behaviors and its structures, the microstructure changes were observed under fluorescence microscopy, laser scanning confocal microscopy and electron microscopy. Our findings demonstrated that down-regulation of ANXA2 results in decreased the cell proliferation and motility, enhanced apoptosis, suppressed cell pseudopodia/filopodia, inhibited expression of F-actin and β-tubulin, and inhibited or depolymerized Lamin B. The cell contact inhibition was also analyzed in the paper. Take together, our results indicate that ANXA2 plays an important role to enhance the malignant behaviors of HCC cells, and the enhancement is closely based on its remodeling to cell structures.
Language eng
DOI 10.1016/j.micron.2016.03.008
Field of Research 119999 Medical and Health Sciences not elsewhere classified
0915 Interdisciplinary Engineering
0204 Condensed Matter Physics
0912 Materials Engineering
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
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Document type: Journal Article
Collection: School of Medicine
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