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A diamond-based electrode for detection of neurochemicals in the human brain

Bennet, Kevin Elliott, Tomshine, Jonathan R., Min, Hoon-Ki, Manciu, Felicia S., Marsh, Michael P., Paek, Seungleal B., Settell, Megan L., Nicolai, Evan N., Blaha, Charles D., Kouzani, Abbas Z., Chang, Su-Youne and Lee, Kendall H. 2016, A diamond-based electrode for detection of neurochemicals in the human brain, Frontiers in human neuroscience, vol. 10, pp. 1-12, doi: 10.3389/fnhum.2016.00102.

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Title A diamond-based electrode for detection of neurochemicals in the human brain
Author(s) Bennet, Kevin Elliott
Tomshine, Jonathan R.
Min, Hoon-Ki
Manciu, Felicia S.
Marsh, Michael P.
Paek, Seungleal B.
Settell, Megan L.
Nicolai, Evan N.
Blaha, Charles D.
Kouzani, Abbas Z.
Chang, Su-Youne
Lee, Kendall H.
Journal name Frontiers in human neuroscience
Volume number 10
Start page 1
End page 12
Total pages 12
Publisher Frontiers Research Foundation
Place of publication Lousanne, Switzerland
Publication date 2016
ISSN 1662-5161
Keyword(s) Science & Technology
Social Sciences
Life Sciences & Biomedicine
Neurosciences
Psychology
Neurosciences & Neurology
diamond-based electrode
dopamine
deep brain stimulation (DBS)
fast scan cyclic voltammetry (FSCV)
carbon fiber microelectrode
neuromodulation
SCAN CYCLIC VOLTAMMETRY
HIGH-FREQUENCY STIMULATION
SUBSECOND DOPAMINE RELEASE
IN-VIVO
SUBTHALAMIC NUCLEUS
NEUROTRANSMITTER RELEASE
ELECTRICAL-STIMULATION
PARKINSONS-DISEASE
BIOLOGICAL-SYSTEMS
RAT MODEL
Summary Deep brain stimulation (DBS), a surgical technique to treat certain neurologic and psychiatric conditions, relies on pre-determined stimulation parameters in an open-loop configuration. The major advancement in DBS devices is a closed-loop system that uses neurophysiologic feedback to dynamically adjust stimulation frequency and amplitude. Stimulation-driven neurochemical release can be measured by fast-scan cyclic voltammetry (FSCV), but existing FSCV electrodes rely on carbon fiber, which degrades quickly during use and is therefore unsuitable for chronic neurochemical recording. To address this issue, we developed durable, synthetic boron-doped diamond-based electrodes capable of measuring neurochemical release in humans. Compared to carbon fiber electrodes, they were more than two orders-of-magnitude more physically-robust and demonstrated longevity in vitro without deterioration. Applied for the first time in humans, diamond electrode recordings from thalamic targets in patients (n = 4) undergoing DBS for tremor produced signals consistent with adenosine release at a sensitivity comparable to carbon fiber electrodes. (Clinical trials # NCT01705301).
Language eng
DOI 10.3389/fnhum.2016.00102
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bennet, Tomshine, Min, Manciu, Marsh, Paek, Settell, Nicolai, Blaha, Kouzani, Chang and Lee
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084759

Document type: Journal Article
Collection: School of Engineering
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